Dietary cyanidin 3-O-beta-D-glucoside-rich purple corn color prevents obesity and ameliorates hyperglycemia in mice - PubMed (original) (raw)
. 2003 Jul;133(7):2125-30.
doi: 10.1093/jn/133.7.2125.
Affiliations
- PMID: 12840166
- DOI: 10.1093/jn/133.7.2125
Dietary cyanidin 3-O-beta-D-glucoside-rich purple corn color prevents obesity and ameliorates hyperglycemia in mice
Takanori Tsuda et al. J Nutr. 2003 Jul.
Abstract
Anthocyanins, which are used as a food coloring, are widely distributed in human diets, suggesting that we ingest large amounts of anthocyanins from plant-based foods. Mice were fed control, cyanidin 3-glucoside-rich purple corn color (PCC), high fat (HF) or HF + PCC diet for 12 wk. Dietary PCC significantly suppressed the HF diet-induced increase in body weight gain, and white and brown adipose tissue weights. Feeding the HF diet markedly induced hypertrophy of the adipocytes in the epididymal white adipose tissue compared with the control group. In contrast, the induction did not occur in the HF + PCC group. The HF diet induced hyperglycemia, hyperinsulinemia and hyperleptinemia. These perturbations were completely normalized in rats fed HF + PCC. An increase in the tumor necrosis factor (TNF)-alpha mRNA level occurred in the HF group and was normalized by dietary PCC. These results suggest that dietary PCC may ameliorate HF diet-induced insulin resistance in mice. PCC suppressed the mRNA levels of enzymes involved in fatty acid and triacylglycerol synthesis and lowered the sterol regulatory element binding protein-1 mRNA level in white adipose tissue. These down-regulations may contribute to triacylglycerol accumulation in white adipose tissue. Our findings provide a biochemical and nutritional basis for the use of PCC or anthocyanins as a functional food factor that may have benefits for the prevention of obesity and diabetes.
Similar articles
- Eriobotrya japonica improves hyperlipidemia and reverses insulin resistance in high-fat-fed mice.
Shih CC, Lin CH, Wu JB. Shih CC, et al. Phytother Res. 2010 Dec;24(12):1769-80. doi: 10.1002/ptr.3143. Phytother Res. 2010. PMID: 20564460 - Cyanidin 3-glucoside ameliorates hyperglycemia and insulin sensitivity due to downregulation of retinol binding protein 4 expression in diabetic mice.
Sasaki R, Nishimura N, Hoshino H, Isa Y, Kadowaki M, Ichi T, Tanaka A, Nishiumi S, Fukuda I, Ashida H, Horio F, Tsuda T. Sasaki R, et al. Biochem Pharmacol. 2007 Dec 3;74(11):1619-27. doi: 10.1016/j.bcp.2007.08.008. Epub 2007 Aug 10. Biochem Pharmacol. 2007. PMID: 17869225 - Dietary diacylglycerol suppresses high fat and high sucrose diet-induced body fat accumulation in C57BL/6J mice.
Murase T, Mizuno T, Omachi T, Onizawa K, Komine Y, Kondo H, Hase T, Tokimitsu I. Murase T, et al. J Lipid Res. 2001 Mar;42(3):372-8. J Lipid Res. 2001. PMID: 11254749 - Dietary sardine protein lowers insulin resistance, leptin and TNF-α and beneficially affects adipose tissue oxidative stress in rats with fructose-induced metabolic syndrome.
Madani Z, Louchami K, Sener A, Malaisse WJ, Ait Yahia D. Madani Z, et al. Int J Mol Med. 2012 Feb;29(2):311-8. doi: 10.3892/ijmm.2011.836. Epub 2011 Nov 11. Int J Mol Med. 2012. PMID: 22085913 - Soya protein β-conglycinin ameliorates fatty liver and obesity in diet-induced obese mice through the down-regulation of PPARγ.
Li D, Ikaga R, Yamazaki T. Li D, et al. Br J Nutr. 2018 Jun;119(11):1220-1232. doi: 10.1017/S0007114518000739. Br J Nutr. 2018. PMID: 29770757
Cited by
- Daily Orange Consumption Reduces Hepatic Steatosis Prevalence in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease: Exploratory Outcomes of a Randomized Clinical Trial.
Notarnicola M, Tutino V, De Nunzio V, Cisternino AM, Cofano M, Donghia R, Giannuzzi V, Zappimbulso M, Milella RA, Giannelli G, Fontana L. Notarnicola M, et al. Nutrients. 2024 Sep 20;16(18):3191. doi: 10.3390/nu16183191. Nutrients. 2024. PMID: 39339791 Free PMC article. Clinical Trial. - Efficacy and Tolerability of a Food Supplement Based on Zea mays L., Gymnema sylvestre (Retz.) R.br.ex Sm, Zinc and Chromium for the Maintenance of Normal Carbohydrate Metabolism: A Monocentric, Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
Buccato DG, Ullah H, De Lellis LF, Morone MV, Larsen DS, Di Minno A, Cordara M, Piccinocchi R, Baldi A, Greco A, Santonastaso S, Sacchi R, Daglia M. Buccato DG, et al. Nutrients. 2024 Jul 29;16(15):2459. doi: 10.3390/nu16152459. Nutrients. 2024. PMID: 39125340 Free PMC article. Clinical Trial. - Combining Different Natural Plant Extracts to Stabilize the Antioxidative Activity of Dragon's Blood.
Su YZ, Lu PL. Su YZ, et al. Life (Basel). 2024 Jun 21;14(7):786. doi: 10.3390/life14070786. Life (Basel). 2024. PMID: 39063541 Free PMC article. - Extraction Effects on Roselle Functionalities: Antioxidant, Antiglycation, and Antibacterial Capacities.
Lai YJ, Chiang YC, Jhan YS, Song TY, Cheng MC. Lai YJ, et al. Foods. 2024 Jul 9;13(14):2172. doi: 10.3390/foods13142172. Foods. 2024. PMID: 39063256 Free PMC article. - Clinical applications and mechanism insights of natural flavonoids against type 2 diabetes mellitus.
Bouyahya A, Balahbib A, Khalid A, Makeen HA, Alhazmi HA, Albratty M, Hermansyah A, Ming LC, Goh KW, El Omari N. Bouyahya A, et al. Heliyon. 2024 Apr 16;10(9):e29718. doi: 10.1016/j.heliyon.2024.e29718. eCollection 2024 May 15. Heliyon. 2024. PMID: 38694079 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials
Miscellaneous