gamma-Glutamyltransferase isoenzyme pattern in workers exposed to tetrachloroethylene - PubMed (original) (raw)
Comparative Study
gamma-Glutamyltransferase isoenzyme pattern in workers exposed to tetrachloroethylene
P Gennari et al. Am J Ind Med. 1992.
Abstract
In compliance with the mandatory medical surveillance of workers exposed to tetrachloroethylene (PCE) in Italy, isoenzyme fractioning of serum gamma-glutamyltransferase (GGT) was performed on 141 workers of both sexes and on 130 control subjects. None of the workers showed any clinical symptoms of liver disease and their enzymatic profiles, including AST, ALT, 5'-NU, ALP, and GGT, were within the normal reference limits. A statistically significant increase in total GGT serum level was found in the exposed subjects, which was associated with an increase in one of the two fractions normally present in healthy individuals (GGT-2), as well as with the appearance and progressive increase of the level of a fraction (GGT-4) considered to be an expression of hepato-biliary impairment. Further research is ongoing among these workers, which will clarify whether or not electrophoretic GGT tests may be useful in detecting liver function changes due to occupational exposure to PCE.
Similar articles
- [Preliminary study to evaluate the meaning of GGT fractions analysis in a population of workers previously exposed to asbestos].
Foddis R, Bonotti A, Sderci F, Pistelli A, Pantani E, Franzini M, Paolicchi A, Baggiani A, Cristaudo A. Foddis R, et al. G Ital Med Lav Ergon. 2012 Jul-Sep;34(3 Suppl):565-7. G Ital Med Lav Ergon. 2012. PMID: 23405717 Italian. - Hepatic and gastrointestinal effects in an occupational cohort exposed to 2,3,7,8-tetrachlorodibenzo-para-dioxin.
Calvert GM, Hornung RW, Sweeney MH, Fingerhut MA, Halperin WE. Calvert GM, et al. JAMA. 1992 Apr 22-29;267(16):2209-14. JAMA. 1992. PMID: 1348289 - [Gamma Glutamyltransferase].
Yoshikawa C, Naka K, Shimojo N, Ohkawa J. Yoshikawa C, et al. Nihon Rinsho. 1995 May;53(5):1162-7. Nihon Rinsho. 1995. PMID: 7602773 Review. Japanese. - Gamma-glutamyltransferase and its isoenzymes: progress and problems.
Nemesánszky E, Lott JA. Nemesánszky E, et al. Clin Chem. 1985 Jun;31(6):797-803. Clin Chem. 1985. PMID: 2859933 Review.
Cited by
- Target Organ Metabolism, Toxicity, and Mechanisms of Trichloroethylene and Perchloroethylene: Key Similarities, Differences, and Data Gaps.
Cichocki JA, Guyton KZ, Guha N, Chiu WA, Rusyn I, Lash LH. Cichocki JA, et al. J Pharmacol Exp Ther. 2016 Oct;359(1):110-23. doi: 10.1124/jpet.116.232629. Epub 2016 Aug 10. J Pharmacol Exp Ther. 2016. PMID: 27511820 Free PMC article. Review. - The relationship of liver function tests to mixed exposure to lead and organic solvents.
Chang WJ, Joe KT, Park HY, Jeong JD, Lee DH. Chang WJ, et al. Ann Occup Environ Med. 2013 May 21;25(1):5. doi: 10.1186/2052-4374-25-5. Ann Occup Environ Med. 2013. PMID: 24472152 Free PMC article. - Hepatic ultrasonic changes in workers exposed to perchloroethylene.
Brodkin CA, Daniell W, Checkoway H, Echeverria D, Johnson J, Wang K, Sohaey R, Green D, Redlich C, Gretch D, et al. Brodkin CA, et al. Occup Environ Med. 1995 Oct;52(10):679-85. doi: 10.1136/oem.52.10.679. Occup Environ Med. 1995. PMID: 7489059 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials
Miscellaneous