TP53 tumor suppressor gene: a model for investigating human mutagenesis - PubMed (original) (raw)
Review
TP53 tumor suppressor gene: a model for investigating human mutagenesis
C Caron de Fromentel et al. Genes Chromosomes Cancer. 1992 Jan.
Abstract
More than 350 independent point mutations of the TP53 gene, found in a wide variety of human cancers, were compiled and analysed. From this study, we confirm the presence of four hot-spot regions which colocalize with some highly conserved domains of the protein. We also define a new hot-spot region which is observed predominantly in lung tumors. Analysis of the mutational events suggests the direct involvement of environmental carcinogens in lung tumors and hepatocarcinomas, and spontaneous mutagenesis generating essentially CpG transitions in most of the remaining ones. Furthermore, we demonstrate in this work that the TP53 gene is an informative model with which to study the molecular mechanisms of mutagenesis in the human genome.
Similar articles
- Compilation of somatic mutations of the CDKN2 gene in human cancers: non-random distribution of base substitutions.
Pollock PM, Pearson JV, Hayward NK. Pollock PM, et al. Genes Chromosomes Cancer. 1996 Feb;15(2):77-88. doi: 10.1002/(SICI)1098-2264(199602)15:2<77::AID-GCC1>3.0.CO;2-0. Genes Chromosomes Cancer. 1996. PMID: 8834170 Review. - Characterization of p53 mutations in methylene chloride-induced lung tumors from B6C3F1 mice.
Hegi ME, Söderkvist P, Foley JF, Schoonhoven R, Swenberg JA, Kari F, Maronpot R, Anderson MW, Wiseman RW. Hegi ME, et al. Carcinogenesis. 1993 May;14(5):803-10. doi: 10.1093/carcin/14.5.803. Carcinogenesis. 1993. PMID: 8504472 - p53 mutations in human lung tumors.
Miller CW, Simon K, Aslo A, Kok K, Yokota J, Buys CH, Terada M, Koeffler HP. Miller CW, et al. Cancer Res. 1992 Apr 1;52(7):1695-8. Cancer Res. 1992. PMID: 1312896 - Molecular genetic studies of tumor suppressor gene regions on chromosomes 13 and 17 in colorectal tumors.
Lothe RA, Fossli T, Danielsen HE, Stenwig AE, Nesland JM, Gallie B, Børresen AL. Lothe RA, et al. J Natl Cancer Inst. 1992 Jul 15;84(14):1100-8. doi: 10.1093/jnci/84.14.1100. J Natl Cancer Inst. 1992. PMID: 1619684 - [TP53 mutations and molecular epidemiology].
Otsuka K, Ishioka C. Otsuka K, et al. Gan To Kagaku Ryoho. 2007 May;34(5):683-9. Gan To Kagaku Ryoho. 2007. PMID: 17496437 Review. Japanese.
Cited by
- Transcriptome analysis of Chinese mitten crabs (Eriocheir sinensis) gills in response to ammonia stress.
Wang Z, Wang Y, Guan Y, Chen Z, Zhai Y, Wu Y, Zhou Y, Hu J, Chen L. Wang Z, et al. PeerJ. 2024 Jan 16;12:e16786. doi: 10.7717/peerj.16786. eCollection 2024. PeerJ. 2024. PMID: 38250716 Free PMC article. - Splicing-Disrupting Mutations in Inherited Predisposition to Solid Pediatric Cancer.
Alba-Pavón P, Alaña L, Astigarraga I, Villate O. Alba-Pavón P, et al. Cancers (Basel). 2022 Dec 2;14(23):5967. doi: 10.3390/cancers14235967. Cancers (Basel). 2022. PMID: 36497448 Free PMC article. Review. - MetaRNN: differentiating rare pathogenic and rare benign missense SNVs and InDels using deep learning.
Li C, Zhi D, Wang K, Liu X. Li C, et al. Genome Med. 2022 Oct 8;14(1):115. doi: 10.1186/s13073-022-01120-z. Genome Med. 2022. PMID: 36209109 Free PMC article. - Overcoming the Impact of Hypoxia in Driving Radiotherapy Resistance in Head and Neck Squamous Cell Carcinoma.
Hill RM, Rocha S, Parsons JL. Hill RM, et al. Cancers (Basel). 2022 Aug 26;14(17):4130. doi: 10.3390/cancers14174130. Cancers (Basel). 2022. PMID: 36077667 Free PMC article. Review. - ZetaSuite: computational analysis of two-dimensional high-throughput data from multi-target screens and single-cell transcriptomics.
Hao Y, Zhang S, Shao C, Li J, Zhao G, Zhang DE, Fu XD. Hao Y, et al. Genome Biol. 2022 Jul 25;23(1):162. doi: 10.1186/s13059-022-02729-4. Genome Biol. 2022. PMID: 35879727 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous