Identification of a protein that binds to the SH3 region of Abl and is similar to Bcr and GAP-rho - PubMed (original) (raw)

Comparative Study

. 1992 Aug 7;257(5071):803-6.

doi: 10.1126/science.1379745.

Affiliations

• PMID: 1379745
• DOI: 10.1126/science.1379745

Comparative Study

Identification of a protein that binds to the SH3 region of Abl and is similar to Bcr and GAP-rho

P Cicchetti et al. Science. 1992.

Abstract

A Src homology 3 (SH3) region is a sequence of approximately 50 amino acids found in many nonreceptor tyrosine kinases and other proteins. Deletion of the SH3 region from the protein encoded by the c-abl proto-oncogene activates the protein's transforming capacity, thereby suggesting the participation of the SH3 region in the negative regulation of transformation. A complementary DNA was isolated that encoded a protein, 3BP-1, to which the SH3 region of Abl bound with high specificity and to which SH3 regions from other proteins bound differentially. The sequence of the 3BP-1 protein is similar to that of a COOH-terminal segment of Bcr and to guanosine triphosphatase-activating protein (GAP)-rho, which suggests that it might have GAP activity for Ras-related proteins. The 3BP-1 protein may therefore be a mediator of SH3 function in transformation inhibition and may link tyrosine kinases to Ras-related proteins.

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