Rare occurrence of P53 gene mutations in multiple myeloma - PubMed (original) (raw)
Rare occurrence of P53 gene mutations in multiple myeloma
C Preudhomme et al. Br J Haematol. 1992 Jul.
Abstract
We looked for mutations of exons 5-8 of the P53 gene in bone marrow cell from 37 cases of multiple myeloma, using polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) analysis and DNA sequencing. 25 patients also had cytogenetic analysis. A point mutation, leading to an amino acid change in the P53 protein was found in only one case, involving exon 5. These findings suggest that P53 mutations are very rare in multiple myeloma, and that this disease may be categorized among the few neoplasms where P53 abnormalities have very limited role, if any.
Similar articles
- N-ras and p53 gene mutations are very rare events in multiple myeloma.
Yasuga Y, Hirosawa S, Yamamoto K, Tomiyama J, Nagata K, Aokia N. Yasuga Y, et al. Int J Hematol. 1995 Aug;62(2):91-7. doi: 10.1016/0925-5710(95)00394-8. Int J Hematol. 1995. PMID: 8590778 - p53 gene mutations are rare in patients but common in patient-originating cell lines in multiple myeloma.
Ollikainen H, Syrjänen S, Koskela K, Pelliniemi TT, Pulkki K. Ollikainen H, et al. Scand J Clin Lab Invest. 1997 Jul;57(4):281-9. doi: 10.3109/00365519709099401. Scand J Clin Lab Invest. 1997. PMID: 9249875 - Sporadic mutations of the p53 gene in multiple myeloma and no evidence for germline mutations in three familial multiple myeloma pedigrees.
Willems PM, Kuypers AW, Meijerink JP, Holdrinet RS, Mensink EJ. Willems PM, et al. Leukemia. 1993 Jul;7(7):986-91. Leukemia. 1993. PMID: 8321049 - Exploring the genetic and molecular basis of differences in multiple myeloma of individuals of African and European descent.
Levine AJ, Carpten JD, Murphy M, Hainaut P. Levine AJ, et al. Cell Death Differ. 2024 Jan;31(1):1-8. doi: 10.1038/s41418-023-01236-8. Epub 2023 Nov 24. Cell Death Differ. 2024. PMID: 38001255 Free PMC article. Review. - Integration of Genomics Into Treatment: Are We There Yet?
Morgan GJ, Jones JR. Morgan GJ, et al. Am Soc Clin Oncol Educ Book. 2017;37:569-574. doi: 10.1200/EDBK_175166. Am Soc Clin Oncol Educ Book. 2017. PMID: 28561666 Review.
Cited by
- p53 mutations in multiple myeloma.
Paydaś S, Sahin B, Seyrek E, Zorludemir S. Paydaś S, et al. Mol Pathol. 1997 Dec;50(6):329. doi: 10.1136/mp.50.6.329-a. Mol Pathol. 1997. PMID: 9536285 Free PMC article. No abstract available. - Immunohistochemical analysis of cyclin D1 and p53 in multiple myeloma: relationship to proliferative activity and prognostic significance.
Markovic O, Marisavljevic D, Cemerikic V, Suvajdzic N, Milic N, Colovic M. Markovic O, et al. Med Oncol. 2004;21(1):73-80. doi: 10.1385/MO:21:1:73. Med Oncol. 2004. PMID: 15034217 - Multiple myeloma: increasing evidence for a multistep transformation process.
Hallek M, Bergsagel PL, Anderson KC. Hallek M, et al. Blood. 1998 Jan 1;91(1):3-21. Blood. 1998. PMID: 9414264 Free PMC article. Review. - Understanding the multiple biological aspects leading to myeloma.
Boyle EM, Davies FE, Leleu X, Morgan GJ. Boyle EM, et al. Haematologica. 2014 Apr;99(4):605-12. doi: 10.3324/haematol.2013.097907. Haematologica. 2014. PMID: 24688108 Free PMC article. No abstract available. - p53 gene mutations in multiple myeloma.
Owen RG, Davis SA, Randerson J, Rawstron AC, Davies F, Child JA, Jack AS, Morgan GJ. Owen RG, et al. Mol Pathol. 1997 Feb;50(1):18-20. doi: 10.1136/mp.50.1.18. Mol Pathol. 1997. PMID: 9208809 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials
Miscellaneous