Dicer is essential for mouse development - PubMed (original) (raw)
doi: 10.1038/ng1253. Epub 2003 Oct 5.
Affiliations
- PMID: 14528307
- DOI: 10.1038/ng1253
Dicer is essential for mouse development
Emily Bernstein et al. Nat Genet. 2003 Nov.
Erratum in
- Nat Genet. 2003 Nov;35(3):287
Abstract
To address the biological function of RNA interference (RNAi)-related pathways in mammals, we disrupted the gene Dicer1 in mice. Loss of Dicer1 lead to lethality early in development, with Dicer1-null embryos depleted of stem cells. Coupled with our inability to generate viable Dicer1-null embryonic stem (ES) cells, this suggests a role for Dicer, and, by implication, the RNAi machinery, in maintaining the stem cell population during early mouse development.
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