Association of tau gene polymorphism with Parkinson's disease - PubMed (original) (raw)

Comparative Study

doi: 10.1007/s10072-003-0141-z.

G Annesi, G Nicoletti, P Serra, G Arabia, P Pugliese, D Messina, M Caracciolo, N Romeo, F Annesi, A A Pasqua, P Spadafora, D Civitelli, N Romeo, A Epifanio, L Morgante, A Quattrone

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Comparative Study

Association of tau gene polymorphism with Parkinson's disease

M Zappia et al. Neurol Sci. 2003 Oct.

Abstract

We investigated the segregation of the dinucleotide GT repeat polymorphism in the intron between exons 9 and 10 of the tau gene in 300 patients with Parkinson's disease (PD) and in 197 normal controls. The A3 allele was more frequent in cases than in controls (30% versus 16%, p<0.001), and individuals carrying at least one A3 allele in their genotype had an increased risk of developing PD (odds ratio 2.78, 95% confidence interval 1.81-4.29). No significant differences were found between patients by considering the age at onset and the presence of family history or dementia. Our findings suggest a possible involvement of the tau gene in the pathogenesis of PD.

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