Nitric oxide and cell signaling: modulation of redox tone and protein modification - PubMed (original) (raw)

Review

. 2003 Dec;25(3-4):313-21.

doi: 10.1007/s00726-003-0019-7. Epub 2003 Aug 28.

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• PMID: 14661093
• DOI: 10.1007/s00726-003-0019-7

Review

Nitric oxide and cell signaling: modulation of redox tone and protein modification

A Landar et al. Amino Acids. 2003 Dec.

Abstract

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) have an impact on many cellular processes, often serving as signal transducers in both physiological and pathological situations. These small molecules can act as ligands for receptors as is the case for nitric oxide and guanylate cyclase. However, they can also modify proteins, changing their function and establishing a baseline for other signals in a process that we have termed "redox tone." In this review, we discuss the different mechanisms of redox cell signaling, and give specific examples of RNS participation in cell signaling via classical and redox tone pathways.

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