FGFR3 and TP53 gene mutations define two distinct pathways in urothelial cell carcinoma of the bladder - PubMed (original) (raw)

. 2003 Dec 1;63(23):8108-12.

Herve Wallerand, François Radvanyi, Jean-Baptiste Lahaye, Serge Pissard, Laure Lecerf, Jean Claude Kouyoumdjian, Claude C Abbou, Jean-Claude Pairon, Marie-Claude Jaurand, Jean-Paul Thiery, Dominique K Chopin, Sixtina Gil Diez de Medina

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FGFR3 and TP53 gene mutations define two distinct pathways in urothelial cell carcinoma of the bladder

Ashraf A Bakkar et al. Cancer Res. 2003.

Abstract

FGFR3 and TP53 mutations are frequent in superficial papillary and invasive disease, respectively. We used denaturing high-performance liquid chromatography and sequencing to screen for FGFR3 and TP53 mutations in 81 newly diagnosed urothelial cell carcinomas. Tumors were classified as follows: 31 pTa, 1 carcinoma in situ, 30 pT1, and 19 pT2-T4. Tumor grades were as follows: 10 G1, 29 G2, and 42 G3. FGFR3 mutations were associated with low-stage (P < 0.0001), low-grade (P < 0.008) tumors, whereas TP53 mutations were associated with high-stage (P < 0.003), high-grade (P < 0.02) tumors. Mutations in these two genes were almost mutually exclusive. Our results suggest that FGFR3 and TP53 mutations define separate pathways at initial diagnosis of urothelial cell carcinoma.

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