Saposins facilitate CD1d-restricted presentation of an exogenous lipid antigen to T cells - PubMed (original) (raw)
doi: 10.1038/ni1034. Epub 2004 Jan 11.
Affiliations
- PMID: 14716312
- DOI: 10.1038/ni1034
Saposins facilitate CD1d-restricted presentation of an exogenous lipid antigen to T cells
Suk-Jo Kang et al. Nat Immunol. 2004 Feb.
Abstract
Members of the CD1 family present antigenic lipids to T lymphocytes. CD1 molecules survey endocytic compartments for lipid antigens that are sorted into these vesicles after incorporation into the membrane bilayer, and extraction from the bilayer is likely to be a critical step for lipid association. We hypothesized that lysosomal saposins, which are cofactors required for sphingolipid degradation, might be involved in this process. Here we show that saposins, although not required for the autoreactive recognition of CD1d by natural killer T cells, are indispensable for the binding of an exogenous lipid antigen, alpha-galactosylceramide, to CD1d in the endocytic pathway. We suggest that saposins mobilize monomeric lipids from lysosomal membranes and facilitate their association with CD1d.
Comment in
- Presenting fats with SAPs.
Kronenberg M. Kronenberg M. Nat Immunol. 2004 Feb;5(2):126-7. doi: 10.1038/ni0204-126. Nat Immunol. 2004. PMID: 14749781 No abstract available.
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