Locomotion of monocytes on endothelium is a critical step during extravasation - PubMed (original) (raw)
doi: 10.1038/ni1051. Epub 2004 Mar 14.
Affiliations
- PMID: 15021878
- DOI: 10.1038/ni1051
Locomotion of monocytes on endothelium is a critical step during extravasation
Alan R Schenkel et al. Nat Immunol. 2004 Apr.
Abstract
Monocytes, like all leukocytes, undergo a series of sequential steps during extravasation from blood into tissues: tethering, rolling, adhesion and diapedesis. We have discovered an essential step, which we call locomotion, in which the monocyte moves from a site of firm adhesion to the nearest junction to begin diapedesis. Blocking CD11a-CD18 and CD11b-CD18 on human monocytes or adhesion molecules ICAM-1 and ICAM-2 on endothelial cells prevented the monocytes from reaching junctions. The blocked monocytes spun in circles as if they were unable to direct their movement despite being able to adhere and polarize normally. This step fills a gap in the paradigm of extravasation as a multistep process.
Comment in
- Crawling and INTEGRating apical cues.
Alon R, Luscinskas FW. Alon R, et al. Nat Immunol. 2004 Apr;5(4):351-3. doi: 10.1038/ni0404-351. Nat Immunol. 2004. PMID: 15052260 No abstract available.
Similar articles
- VLA-4 integrin can mediate CD11/CD18-independent transendothelial migration of human monocytes.
Chuluyan HE, Issekutz AC. Chuluyan HE, et al. J Clin Invest. 1993 Dec;92(6):2768-77. doi: 10.1172/JCI116895. J Clin Invest. 1993. PMID: 7902847 Free PMC article. - Simvastatin reduces the expression of adhesion molecules in circulating monocytes from hypercholesterolemic patients.
Rezaie-Majd A, Prager GW, Bucek RA, Schernthaner GH, Maca T, Kress HG, Valent P, Binder BR, Minar E, Baghestanian M. Rezaie-Majd A, et al. Arterioscler Thromb Vasc Biol. 2003 Mar 1;23(3):397-403. doi: 10.1161/01.ATV.0000059384.34874.F0. Epub 2003 Jan 30. Arterioscler Thromb Vasc Biol. 2003. PMID: 12615677 Clinical Trial. - Molecular mechanism of blood monocyte adhesion to vascular endothelial cells.
Dosquet C, Weill D, Wautier JL. Dosquet C, et al. Nouv Rev Fr Hematol (1978). 1992;34 Suppl:S55-9. Nouv Rev Fr Hematol (1978). 1992. PMID: 1340530 Review. - Molecular events during leukocyte diapedesis.
Petri B, Bixel MG. Petri B, et al. FEBS J. 2006 Oct;273(19):4399-407. doi: 10.1111/j.1742-4658.2006.05439.x. Epub 2006 Sep 11. FEBS J. 2006. PMID: 16965541 Review.
Cited by
- Monocyte maturation, HIV susceptibility, and transmigration across the blood brain barrier are critical in HIV neuropathogenesis.
Williams DW, Eugenin EA, Calderon TM, Berman JW. Williams DW, et al. J Leukoc Biol. 2012 Mar;91(3):401-15. doi: 10.1189/jlb.0811394. Epub 2012 Jan 6. J Leukoc Biol. 2012. PMID: 22227964 Free PMC article. Review. - Inflammatory Cell Recruitment in Cardiovascular Disease.
Marchini T, Mitre LS, Wolf D. Marchini T, et al. Front Cell Dev Biol. 2021 Feb 18;9:635527. doi: 10.3389/fcell.2021.635527. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 33681219 Free PMC article. Review. - Dysregulation of Leukocyte Trafficking in Type 2 Diabetes: Mechanisms and Potential Therapeutic Avenues.
Pezhman L, Tahrani A, Chimen M. Pezhman L, et al. Front Cell Dev Biol. 2021 Feb 22;9:624184. doi: 10.3389/fcell.2021.624184. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 33692997 Free PMC article. Review. - Recent developments and complexities in neutrophil transmigration.
Woodfin A, Voisin MB, Nourshargh S. Woodfin A, et al. Curr Opin Hematol. 2010 Jan;17(1):9-17. doi: 10.1097/MOH.0b013e3283333930. Curr Opin Hematol. 2010. PMID: 19864945 Free PMC article. Review. - Coordinated RhoA signaling at the leading edge and uropod is required for T cell transendothelial migration.
Heasman SJ, Carlin LM, Cox S, Ng T, Ridley AJ. Heasman SJ, et al. J Cell Biol. 2010 Aug 23;190(4):553-63. doi: 10.1083/jcb.201002067. J Cell Biol. 2010. PMID: 20733052 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous