Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD - PubMed (original) (raw)

. 2004 Apr 23;304(5670):596-600.

doi: 10.1126/science.1095569.

Affiliations

• PMID: 15105503
• DOI: 10.1126/science.1095569

Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD

Andrei V Budanov et al. Science. 2004.

Abstract

Acting as a signal, hydrogen peroxide circumvents antioxidant defense by overoxidizing peroxiredoxins (Prxs), the enzymes that metabolize peroxides. We show that sestrins, a family of proteins whose expression is modulated by p53, are required for regeneration of Prxs containing Cys-SO(2)H, thus reestablishing the antioxidant firewall. Sestrins contain a predicted redox-active domain homologous to AhpD, the enzyme catalyzing the reduction of a bacterial Prx, AhpC. Purified Hi95 (sestrin 2) protein supports adenosine triphosphate-dependent reduction of overoxidized PrxI in vitro, indicating that unlike AhpD, which is a disulfide reductase, sestrins are cysteine sulfinyl reductases. As modulators of peroxide signaling and antioxidant defense, sestrins constitute potential therapeutic targets.

PubMed Disclaimer

Similar articles

• Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein.
  Bryk R, Lima CD, Erdjument-Bromage H, Tempst P, Nathan C. Bryk R, et al. Science. 2002 Feb 8;295(5557):1073-7. doi: 10.1126/science.1067798. Epub 2002 Jan 17. Science. 2002. PMID: 11799204
• The Arabidopsis thaliana sulfiredoxin is a plastidic cysteine-sulfinic acid reductase involved in the photooxidative stress response.
  Rey P, Bécuwe N, Barrault MB, Rumeau D, Havaux M, Biteau B, Toledano MB. Rey P, et al. Plant J. 2007 Feb;49(3):505-14. doi: 10.1111/j.1365-313X.2006.02969.x. Epub 2007 Jan 1. Plant J. 2007. PMID: 17217469
• Mouse peroxiredoxin V is a thioredoxin peroxidase that inhibits p53-induced apoptosis.
  Zhou Y, Kok KH, Chun AC, Wong CM, Wu HW, Lin MC, Fung PC, Kung H, Jin DY. Zhou Y, et al. Biochem Biophys Res Commun. 2000 Feb 24;268(3):921-7. doi: 10.1006/bbrc.2000.2231. Biochem Biophys Res Commun. 2000. PMID: 10679306
• Multiple functions of peroxiredoxins: peroxidases, sensors and regulators of the intracellular messenger H₂O₂, and protein chaperones.
  Rhee SG, Woo HA. Rhee SG, et al. Antioxid Redox Signal. 2011 Aug 1;15(3):781-94. doi: 10.1089/ars.2010.3393. Epub 2011 Mar 31. Antioxid Redox Signal. 2011. PMID: 20919930 Review.
• The plant multigenic family of thiol peroxidases.
  Rouhier N, Jacquot JP. Rouhier N, et al. Free Radic Biol Med. 2005 Jun 1;38(11):1413-21. doi: 10.1016/j.freeradbiomed.2004.07.037. Free Radic Biol Med. 2005. PMID: 15890615 Review.

Cited by

• Hydrogen peroxide sensing and signaling by protein kinases in the cardiovascular system.
  Burgoyne JR, Oka S, Ale-Agha N, Eaton P. Burgoyne JR, et al. Antioxid Redox Signal. 2013 Mar 20;18(9):1042-52. doi: 10.1089/ars.2012.4817. Epub 2012 Sep 17. Antioxid Redox Signal. 2013. PMID: 22867279 Free PMC article. Review.
• Transcriptional Profiling of Porcine Blastocysts Produced In Vitro in a Chemically Defined Culture Medium.
  Cambra JM, Martinez EA, Rodriguez-Martinez H, Gil MA, Cuello C. Cambra JM, et al. Animals (Basel). 2021 May 14;11(5):1414. doi: 10.3390/ani11051414. Animals (Basel). 2021. PMID: 34069238 Free PMC article.
• Sesn3 deficiency promotes carcinogen-induced hepatocellular carcinoma via regulation of the hedgehog pathway.
  Liu Y, Kim HG, Dong E, Dong C, Huang M, Liu Y, Liangpunsakul S, Dong XC. Liu Y, et al. Biochim Biophys Acta Mol Basis Dis. 2019 Oct 1;1865(10):2685-2693. doi: 10.1016/j.bbadis.2019.07.011. Epub 2019 Jul 24. Biochim Biophys Acta Mol Basis Dis. 2019. PMID: 31351129 Free PMC article.
• Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies.
  Lee JH, Budanov AV, Park EJ, Birse R, Kim TE, Perkins GA, Ocorr K, Ellisman MH, Bodmer R, Bier E, Karin M. Lee JH, et al. Science. 2010 Mar 5;327(5970):1223-8. doi: 10.1126/science.1182228. Science. 2010. PMID: 20203043 Free PMC article.
• PRDX5 as a novel binding partner in Nrf2-mediated NSCLC progression under oxidative stress.
  Chen X, Cao X, Xiao W, Li B, Xue Q. Chen X, et al. Aging (Albany NY). 2020 Jan 3;12(1):122-137. doi: 10.18632/aging.102605. Epub 2020 Jan 3. Aging (Albany NY). 2020. PMID: 31899687 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon
  • Ovid Technologies, Inc.

• Other Literature Sources

  • The Lens - Patent Citations Database

• Molecular Biology Databases

  • BioCyc
  • Gene Ontology
  • GlyGen glycoinformatics resource

• Research Materials

  • NCI CPTC Antibody Characterization Program

• Miscellaneous

  • NCI CPTAC Assay Portal