p53 designer genes for the modern mouse - PubMed (original) (raw)
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p53 designer genes for the modern mouse
Manfred Hergenhahn et al. Cell Cycle. 2004 Jun.
Abstract
Major efforts are underway to develop molecular strategies that target the p53 pathway for the treatment of cancer. Mouse strains with humanized p53 sequences that present the precise human DNA-binding domain as mutation target could be informative models to test p53 rescue drugs, and to explore experimentally the causes of human tumor mutations.
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