Deficit in attachment behavior in mice lacking the mu-opioid receptor gene - PubMed (original) (raw)
. 2004 Jun 25;304(5679):1983-6.
doi: 10.1126/science.1095943.
Affiliations
- PMID: 15218152
- DOI: 10.1126/science.1095943
Deficit in attachment behavior in mice lacking the mu-opioid receptor gene
Anna Moles et al. Science. 2004.
Abstract
Endogenous opioid binding to micro receptors is hypothesized to mediate natural rewards and has been proposed to be the basis of infant attachment behavior. Here, we report that micro-opioid receptor knockout mouse pups emit fewer ultrasonic vocalizations when removed from their mothers but not when exposed to cold or male mice odors. Moreover these knockout pups do not show a preference toward their mothers' cues and do not show ultrasonic calls potentiation after brief maternal exposure. Results from this study may indicate a molecular mechanism for diseases characterized by deficits in attachment behavior, such as autism or reactive attachment disorder.
Comment in
- Neuroscience. The mice that don't miss mom: love and the mu-opioid receptor.
Beckman M. Beckman M. Science. 2004 Jun 25;304(5679):1888-9. doi: 10.1126/science.304.5679.1888a. Science. 2004. PMID: 15218114 No abstract available. - Autism and deficits in attachment behavior.
Gernsbacher MA, Dissanayake C, Goldsmith HH, Mundy PC, Rogers SJ, Sigman M. Gernsbacher MA, et al. Science. 2005 Feb 25;307(5713):1201-3; author reply 1201-3. doi: 10.1126/science.307.5713.1201. Science. 2005. PMID: 15731426 Free PMC article. No abstract available.
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