The multifaceted roles of TRAFs in the regulation of B-cell function - PubMed (original) (raw)
Review
doi: 10.1038/nri1462.
Affiliations
- PMID: 15459669
- DOI: 10.1038/nri1462
Review
The multifaceted roles of TRAFs in the regulation of B-cell function
Gail A Bishop. Nat Rev Immunol. 2004 Oct.
Abstract
Tumour-necrosis factor receptor (TNFR)-associated factors (TRAFs) are cytoplasmic adaptor proteins that are important in lymphocyte activation and apoptosis. Many studies of TRAFs have used models of exogenous overexpression by non-lymphoid cells. However, the actions of TRAFs present at normal levels in lymphoid cells often differ considerably from those that have been established in non-lymphocyte overexpression models. As I discuss here, information obtained from studying these molecules in physiological settings in B cells reveals that they have several roles, which are both unique and overlapping. These include activation of kinases and transcription factors, and interactions with other signalling proteins, culminating in the induction or inhibition of biological functions.
Similar articles
- Outside inside signalling in CD40-mediated B cell activation.
D'Orlando O, Gri G, Cattaruzzi G, Merluzzi S, Betto E, Gattei V, Pucillo C. D'Orlando O, et al. J Biol Regul Homeost Agents. 2007;21(3-4):49-62. J Biol Regul Homeost Agents. 2007. PMID: 18261257 Review. - Double knockout mice show BASH and PKCdelta have different epistatic relationships in B cell maturation and CD40-mediated activation.
Nojima T, Hayashi K, Goitsuka R, Nakayama K, Nakayama K, Kitamura D. Nojima T, et al. Immunol Lett. 2006 May 15;105(1):48-54. doi: 10.1016/j.imlet.2005.12.004. Epub 2006 Jan 25. Immunol Lett. 2006. PMID: 16481047 - TRAF2 and p38 are involved in B cells CD40-mediated APE/Ref-1 nuclear translocation: a novel pathway in B cell activation.
Merluzzi S, D'Orlando O, Leonardi A, Vitale G, Pucillo C. Merluzzi S, et al. Mol Immunol. 2008 Jan;45(1):76-86. doi: 10.1016/j.molimm.2007.05.010. Epub 2007 Jun 27. Mol Immunol. 2008. PMID: 17599408 - Interference with nuclear factor kappa B and c-Jun NH2-terminal kinase signaling by TRAF6C small interfering RNA inhibits myeloma cell proliferation and enhances apoptosis.
Chen H, Li M, Campbell RA, Burkhardt K, Zhu D, Li SG, Lee HJ, Wang C, Zeng Z, Gordon MS, Bonavida B, Berenson JR. Chen H, et al. Oncogene. 2006 Oct 19;25(49):6520-7. doi: 10.1038/sj.onc.1209653. Epub 2006 May 15. Oncogene. 2006. PMID: 16702955 - Assembly of post-receptor signaling complexes for the tumor necrosis factor receptor superfamily.
Wu H. Wu H. Adv Protein Chem. 2004;68:225-79. doi: 10.1016/S0065-3233(04)68007-7. Adv Protein Chem. 2004. PMID: 15500863 Review.
Cited by
- The effects of Jieduquyuzishen prescription-treated rat serum on the BAFF/BAFF-R signal pathway.
Wu DH, Xu L, Wen CP, Xie GQ, Ji JJ, Pan JL, Jiao YF, Fan YS. Wu DH, et al. PLoS One. 2015 Feb 17;10(2):e0118462. doi: 10.1371/journal.pone.0118462. eCollection 2015. PLoS One. 2015. PMID: 25689512 Free PMC article. - Tumor necrosis factor receptor-associated factor 3 is a critical regulator of B cell homeostasis in secondary lymphoid organs.
Xie P, Stunz LL, Larison KD, Yang B, Bishop GA. Xie P, et al. Immunity. 2007 Aug;27(2):253-67. doi: 10.1016/j.immuni.2007.07.012. Immunity. 2007. PMID: 17723217 Free PMC article. - FOXP1 directly represses transcription of proapoptotic genes and cooperates with NF-κB to promote survival of human B cells.
van Keimpema M, Grüneberg LJ, Mokry M, van Boxtel R, Koster J, Coffer PJ, Pals ST, Spaargaren M. van Keimpema M, et al. Blood. 2014 Nov 27;124(23):3431-40. doi: 10.1182/blood-2014-01-553412. Epub 2014 Sep 29. Blood. 2014. PMID: 25267198 Free PMC article. - Multiple roles of TRAF3 signaling in lymphocyte function.
Bishop GA, Xie P. Bishop GA, et al. Immunol Res. 2007;39(1-3):22-32. doi: 10.1007/s12026-007-0068-1. Immunol Res. 2007. PMID: 17917053 Review. - Genetics and epigenetics of autoimmune thyroid diseases: Translational implications.
Lee HJ, Stefan-Lifshitz M, Li CW, Tomer Y. Lee HJ, et al. Best Pract Res Clin Endocrinol Metab. 2023 Mar;37(2):101661. doi: 10.1016/j.beem.2022.101661. Epub 2022 Apr 11. Best Pract Res Clin Endocrinol Metab. 2023. PMID: 35459628 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials