Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island - PubMed (original) (raw)

. 2004 Nov;5(11):1166-74.

doi: 10.1038/ni1131. Epub 2004 Oct 17.

Catherine Chaput, Ivo G Boneca, Ana Cardona, Stephen E Girardin, Anthony P Moran, Rafika Athman, Sylvie Mémet, Michel R Huerre, Anthony J Coyle, Peter S DiStefano, Philippe J Sansonetti, Agnès Labigne, John Bertin, Dana J Philpott, Richard L Ferrero

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Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island

Jérôme Viala et al. Nat Immunol. 2004 Nov.

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Abstract

Epithelial cells can respond to conserved bacterial products that are internalized after either bacterial invasion or liposome treatment of cells. We report here that the noninvasive Gram-negative pathogen Helicobacter pylori was recognized by epithelial cells via Nod1, an intracellular pathogen-recognition molecule with specificity for Gram-negative peptidoglycan. Nod1 detection of H. pylori depended on the delivery of peptidoglycan to host cells by a bacterial type IV secretion system, encoded by the H. pylori cag pathogenicity island. Consistent with involvement of Nod1 in host defense, Nod1-deficient mice were more susceptible to infection by cag pathogenicity island-positive H. pylori than were wild-type mice. We propose that sensing of H. pylori by Nod1 represents a model for host recognition of noninvasive pathogens.

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