Central infusion of agouti-related peptide suppresses pulsatile luteinizing hormone release in the ovariectomized rhesus monkey - PubMed (original) (raw)
Central infusion of agouti-related peptide suppresses pulsatile luteinizing hormone release in the ovariectomized rhesus monkey
Nicolas R Vulliémoz et al. Endocrinology. 2005 Feb.
Abstract
Agouti-related peptide (AGRP), an endogenous melanocortin receptor antagonist, is a powerful orexigenic peptide when infused centrally. AGRP and neuropeptide Y (NPY), another orexigenic peptide, are colocated within the same neurons in the arcuate nucleus. Both NPY and AGRP mRNA expression increases during food restriction, a condition that is known to suppress the GnRH pulse generator and reproductive function. Although NPY has been shown previously to suppress LH secretion in the ovariectomized monkey, data on AGRP are lacking. In this study, we examined the effect of AGRP infusion into the third ventricle on pulsatile LH release in five adult monkeys. The 8-h protocol included a 3-h intraventricular saline infusion to establish baseline pulsatile LH release, followed by a 5-h infusion of AGRP (83-132) [5 microg/h (n=1) or 10 microg/h (n=4)]. In separate experiments, each animal received an 8-h saline treatment as a control. Blood samples were collected every 15 min for LH measurements. Cortisol levels were measured every 45 min. AGRP infusion significantly decreased LH pulse frequency (from a baseline of 0.74 +/- 0.07 pulse/h to 0.36 +/- 0.12 during AGRP infusion; P <0.01) and mean LH concentrations (to 41.1 +/- 7.5% of baseline by h 5 of AGRP infusion; P < 0.001). LH pulse amplitude was not modified by AGRP treatment. AGRP infusion also significantly increased cortisol release, as previously reported. The data demonstrate that central administration of AGRP inhibits pulsatile LH release in the monkey and suggest that AGRP, like NPY, may mediate the effect of a negative energy balance on the reproductive system by suppressing the GnRH pulse generator.
Similar articles
- Decrease in luteinizing hormone pulse frequency during a five-hour peripheral ghrelin infusion in the ovariectomized rhesus monkey.
Vulliémoz NR, Xiao E, Xia-Zhang L, Germond M, Rivier J, Ferin M. Vulliémoz NR, et al. J Clin Endocrinol Metab. 2004 Nov;89(11):5718-23. doi: 10.1210/jc.2004-1244. J Clin Endocrinol Metab. 2004. PMID: 15531534 - Third-ventricular infusion of neuropeptide Y suppresses luteinizing hormone secretion in ovariectomized rhesus macaques.
Kaynard AH, Pau KY, Hess DL, Spies HG. Kaynard AH, et al. Endocrinology. 1990 Nov;127(5):2437-44. doi: 10.1210/endo-127-5-2437. Endocrinology. 1990. PMID: 2226326 - Pulsatile luteinizing hormone secretion in patients with Addison's disease. Impact of glucocorticoid substitution.
Hangaard J, Andersen M, Grodum E, Koldkjaer O, Hagen C. Hangaard J, et al. J Clin Endocrinol Metab. 1998 Mar;83(3):736-43. doi: 10.1210/jcem.83.3.4671. J Clin Endocrinol Metab. 1998. PMID: 9506718 Review. - The hypothalamic gonadotrophic hormone releasing hormone (GnRH) pulse generator in the rhesus monkey and its neuroendocrine control.
Knobil E. Knobil E. Hum Reprod. 1988 Jan;3(1):29-31. doi: 10.1093/oxfordjournals.humrep.a136647. Hum Reprod. 1988. PMID: 3280593 Review. No abstract available.
Cited by
- Estrogen receptor-α signaling in tanycytes lies at the crossroads of fertility and metabolism.
Fernandois D, Rusidzé M, Mueller-Fielitz H, Sauve F, Deligia E, Silva MSB, Evrard F, Franco-García A, Mazur D, Martinez-Corral I, Jouy N, Rasika S, Maurage CA, Giacobini P, Nogueiras R, Dehouck B, Schwaninger M, Lenfant F, Prevot V. Fernandois D, et al. Metabolism. 2024 Sep;158:155976. doi: 10.1016/j.metabol.2024.155976. Epub 2024 Jul 15. Metabolism. 2024. PMID: 39019342 Free PMC article. - KNDy neurons as the GnRH pulse generator: Recent studies in ruminants.
Nestor CC, Merkley CM, Lehman MN, Hileman SM, Goodman RL. Nestor CC, et al. Peptides. 2023 Jun;164:171005. doi: 10.1016/j.peptides.2023.171005. Epub 2023 Mar 27. Peptides. 2023. PMID: 36990389 Free PMC article. Review. - Neuroendocrine signaling pathways and the nutritional control of puberty in heifers.
Cardoso RC, Alves BRC, Williams GL. Cardoso RC, et al. Anim Reprod. 2018 Aug 3;15(Suppl 1):868-878. doi: 10.21451/1984-3143-AR2018-0013. eCollection 2018 Jul-Sep. Anim Reprod. 2018. PMID: 36249846 Free PMC article. - Effects of low energy availability on female reproductive function.
Iwasa T, Minato S, Imaizumi J, Yoshida A, Kawakita T, Yoshida K, Yamamoto Y. Iwasa T, et al. Reprod Med Biol. 2021 Sep 20;21(1):e12414. doi: 10.1002/rmb2.12414. eCollection 2022 Jan. Reprod Med Biol. 2021. PMID: 34934398 Free PMC article. Review. - Evidence That Agouti-Related Peptide May Directly Regulate Kisspeptin Neurons in Male Sheep.
Merkley CM, Shuping SL, Sommer JR, Nestor CC. Merkley CM, et al. Metabolites. 2021 Feb 26;11(3):138. doi: 10.3390/metabo11030138. Metabolites. 2021. PMID: 33652696 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous