Targeting Rab GTPases to distinct membrane compartments - PubMed (original) (raw)

Review

doi: 10.1038/nrm1500.

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Review

Targeting Rab GTPases to distinct membrane compartments

Suzanne Pfeffer et al. Nat Rev Mol Cell Biol. 2004 Nov.

Abstract

Rab GTPases are key to membrane-trafficking events in eukaryotic cells, and human cells contain more than 60 Rab proteins that are localized to distinct compartments. The recent determination of the structure of a monoprenylated Rab GTPase bound to GDP-dissociation inhibitor provides new molecular details that are relevant to models of Rab delivery. The further discovery of an integral membrane protein that can dissociate prenylated Rab proteins from GDP-dissociation inhibitor gives new insights into the mechanisms of Rab localization.

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