Intrinsic tumour suppression - PubMed (original) (raw)
Review
. 2004 Nov 18;432(7015):307-15.
doi: 10.1038/nature03098.
Affiliations
- PMID: 15549092
- DOI: 10.1038/nature03098
Review
Intrinsic tumour suppression
Scott W Lowe et al. Nature. 2004.
Abstract
Mutations that drive uncontrolled cell-cycle progression are requisite events in tumorigenesis. But evolution has installed in the proliferative programmes of mammalian cells a variety of innate tumour-suppressive mechanisms that trigger apoptosis or senescence, should proliferation become aberrant. These contingent processes rely on a series of sensors and transducers that act in a coordinated network to target the machinery responsible for apoptosis and cell-cycle arrest at different points. Although oncogenic mutations that disable such networks can have profound and varied effects on tumour evolution, they may leave intact latent tumour-suppressive potential that can be harnessed therapeutically.
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