Brahma links the SWI/SNF chromatin-remodeling complex with MeCP2-dependent transcriptional silencing - PubMed (original) (raw)
doi: 10.1038/ng1516. Epub 2005 Feb 6.
Affiliations
- PMID: 15696166
- DOI: 10.1038/ng1516
Brahma links the SWI/SNF chromatin-remodeling complex with MeCP2-dependent transcriptional silencing
K N Harikrishnan et al. Nat Genet. 2005 Mar.
Abstract
Transcriptional repression of methylated genes can be mediated by the methyl-CpG binding protein MeCP2. Here we show that human Brahma (Brm), a catalytic component of the SWI/SNF-related chromatin-remodeling complex, associates with MeCP2 in vivo and is functionally linked with repression. We used a number of different molecular approaches and chromatin immunoprecipitation strategies to show a unique cooperation between Brm, BAF57 and MeCP2. We show that Brm and MeCP2 assembly on chromatin occurs on methylated genes in cancer and the gene FMR1 in fragile X syndrome. These experimental findings identify a new role for SWI/SNF in gene repression by MeCP2.
Comment in
- SWItching off methylated DNA.
Wade PA. Wade PA. Nat Genet. 2005 Mar;37(3):212-3. doi: 10.1038/ng0305-212. Nat Genet. 2005. PMID: 15731752 No abstract available. - Testing for association between MeCP2 and the brahma-associated SWI/SNF chromatin-remodeling complex.
Hu K, Nan X, Bird A, Wang W. Hu K, et al. Nat Genet. 2006 Sep;38(9):962-4; author reply 964-7. doi: 10.1038/ng0906-962. Nat Genet. 2006. PMID: 16940996 No abstract available.
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