Regulation of plasma-cell development - PubMed (original) (raw)
Review
doi: 10.1038/nri1572.
Affiliations
- PMID: 15738953
- DOI: 10.1038/nri1572
Review
Regulation of plasma-cell development
Miriam Shapiro-Shelef et al. Nat Rev Immunol. 2005 Mar.
Abstract
Plasma cells are the terminally differentiated, non-dividing effector cells of the B-cell lineage. They are cellular factories devoted to the task of synthesizing and secreting thousands of molecules of clonospecific antibody each second. To respond to microbial pathogens with the necessary specificity and rapidity, B cells are exquisitely regulated with respect to both development in the bone marrow and activation in the periphery. This review focuses on the terminal differentiation of B cells into plasma cells, including the different subsets of B cells that become plasma cells, the mechanism of regulation of this transition, the transcription factors that control each developmental stage and the characteristics of long-lived plasma cells.
Similar articles
- IL-21 and IL-10 have redundant roles but differential capacities at different stages of Plasma Cell generation from human Germinal Center B cells.
Yoon SO, Zhang X, Berner P, Choi YS. Yoon SO, et al. J Leukoc Biol. 2009 Dec;86(6):1311-8. doi: 10.1189/jlb.0409268. Epub 2009 Sep 17. J Leukoc Biol. 2009. PMID: 19762555 - Plasma cells: finding new light at the end of B cell development.
Calame KL. Calame KL. Nat Immunol. 2001 Dec;2(12):1103-8. doi: 10.1038/ni1201-1103. Nat Immunol. 2001. PMID: 11725300 Review. - Increased IL-12 inhibits B cells' differentiation to germinal center cells and promotes differentiation to short-lived plasmablasts.
Kim SJ, Caton M, Wang C, Khalil M, Zhou ZJ, Hardin J, Diamond B. Kim SJ, et al. J Exp Med. 2008 Sep 29;205(10):2437-48. doi: 10.1084/jem.20070731. Epub 2008 Sep 22. J Exp Med. 2008. PMID: 18809711 Free PMC article. - Analysis of the germinal center reaction and in vivo long-lived plasma cells.
Toellner KM, Khan M, Sze DM. Toellner KM, et al. Methods Mol Biol. 2004;271:111-25. doi: 10.1385/1-59259-796-3:111. Methods Mol Biol. 2004. PMID: 15146116 - Differentiation and maintenance of long-lived plasma cells.
Kometani K, Kurosaki T. Kometani K, et al. Curr Opin Immunol. 2015 Apr;33:64-9. doi: 10.1016/j.coi.2015.01.017. Epub 2015 Feb 9. Curr Opin Immunol. 2015. PMID: 25677584 Review.
Cited by
- Ferroptosis contributes to immunosuppression.
He N, Yuan D, Luo M, Xu Q, Wen Z, Wang Z, Zhao J, Liu Y. He N, et al. Front Med. 2024 Nov 19. doi: 10.1007/s11684-024-1080-8. Online ahead of print. Front Med. 2024. PMID: 39560919 Review. - The Dual Role of B Cells in the Tumor Microenvironment: Implications for Cancer Immunology and Therapy.
Yang H, Zhang Z, Li J, Wang K, Zhu W, Zeng Y. Yang H, et al. Int J Mol Sci. 2024 Nov 4;25(21):11825. doi: 10.3390/ijms252111825. Int J Mol Sci. 2024. PMID: 39519376 Free PMC article. Review. - Transcriptional rewiring in CD8+ T cells: implications for CAR-T cell therapy against solid tumours.
Srinivasan S, Armitage J, Nilsson J, Waithman J. Srinivasan S, et al. Front Immunol. 2024 Sep 27;15:1412731. doi: 10.3389/fimmu.2024.1412731. eCollection 2024. Front Immunol. 2024. PMID: 39399500 Free PMC article. Review. - YY1 knockout in pro-B cells impairs lineage commitment, enabling unusual hematopoietic lineage plasticity.
Banerjee S, Sanyal S, Hodawadekar S, Naiyer S, Bano N, Banerjee A, Rhoades J, Dong D, Allman D, Atchison ML. Banerjee S, et al. Genes Dev. 2024 Oct 16;38(17-20):887-914. doi: 10.1101/gad.351734.124. Genes Dev. 2024. PMID: 39362773 - IgG-k/IgG-λ Para-Osseous Plasmacytoma Relapsed as Soft-Tissue Plasmacytoma with IgA-k Immunophenotype: A Case Report and Review of the Literature on Related Biochemical Aspects.
Fazio M, Sorbello CMC, Del Fabro V, Romano A, Cannizzaro MT, Parrinello NL, Esposito B, Frazzetto S, Elia F, Di Raimondo F, Conticello C. Fazio M, et al. Hematol Rep. 2024 Aug 29;16(3):541-551. doi: 10.3390/hematolrep16030052. Hematol Rep. 2024. PMID: 39311139 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources