TNF/TNFR family members in costimulation of T cell responses - PubMed (original) (raw)
Review
TNF/TNFR family members in costimulation of T cell responses
Tania H Watts. Annu Rev Immunol. 2005.
Abstract
Several members of the tumor necrosis factor receptor (TNFR) family function after initial T cell activation to sustain T cell responses. This review focuses on CD27, 4-1BB (CD137), OX40 (CD134), HVEM, CD30, and GITR, all of which can have costimulatory effects on T cells. The effects of these costimulatory TNFR family members can often be functionally, temporally, or spatially segregated from those of CD28 and from each other. The sequential and transient regulation of T cell activation/survival signals by different costimulators may function to allow longevity of the response while maintaining tight control of T cell survival. Depending on the disease condition, stimulation via costimulatory TNF family members can exacerbate or ameliorate disease. Despite these complexities, stimulation or blockade of TNFR family costimulators shows promise for several therapeutic applications, including cancer, infectious disease, transplantation, and autoimmunity.
Similar articles
- Co-stimulatory members of the TNFR family: keys to effective T-cell immunity?
Croft M. Croft M. Nat Rev Immunol. 2003 Aug;3(8):609-20. doi: 10.1038/nri1148. Nat Rev Immunol. 2003. PMID: 12974476 Review. - Contribution of CD30/CD153 but not of CD27/CD70, CD134/OX40L, or CD137/4-1BBL to the optimal induction of protective immunity to Mycobacterium avium.
Flórido M, Borges M, Yagita H, Appelberg R. Flórido M, et al. J Leukoc Biol. 2004 Nov;76(5):1039-46. doi: 10.1189/jlb.1103572. Epub 2004 Aug 17. J Leukoc Biol. 2004. PMID: 15316035 - Role of T cell costimulation in anti-viral immunity.
Bertram EM, Dawicki W, Watts TH. Bertram EM, et al. Semin Immunol. 2004 Jun;16(3):185-96. doi: 10.1016/j.smim.2004.02.006. Semin Immunol. 2004. PMID: 15130503 Review. - Timing and tuning of CD27-CD70 interactions: the impact of signal strength in setting the balance between adaptive responses and immunopathology.
Nolte MA, van Olffen RW, van Gisbergen KP, van Lier RA. Nolte MA, et al. Immunol Rev. 2009 May;229(1):216-31. doi: 10.1111/j.1600-065X.2009.00774.x. Immunol Rev. 2009. PMID: 19426224 Review. - Costimulation of T cells by OX40, 4-1BB, and CD27.
Croft M. Croft M. Cytokine Growth Factor Rev. 2003 Jun-Aug;14(3-4):265-73. doi: 10.1016/s1359-6101(03)00025-x. Cytokine Growth Factor Rev. 2003. PMID: 12787564 Review.
Cited by
- Association between tumor necrosis factor-alpha 857C/T polymorphism and gastric cancer: a meta-analysis.
Cen G, Wu W. Cen G, et al. Tumour Biol. 2013 Dec;34(6):3383-8. doi: 10.1007/s13277-013-0910-0. Epub 2013 Jul 3. Tumour Biol. 2013. PMID: 23821300 - CD134/CD137 dual costimulation-elicited IFN-γ maximizes effector T-cell function but limits Treg expansion.
St Rose MC, Taylor RA, Bandyopadhyay S, Qui HZ, Hagymasi AT, Vella AT, Adler AJ. St Rose MC, et al. Immunol Cell Biol. 2013 Feb;91(2):173-83. doi: 10.1038/icb.2012.74. Epub 2013 Jan 8. Immunol Cell Biol. 2013. PMID: 23295363 Free PMC article. - Monocyte-derived dendritic cells from cirrhotic patients retain similar capacity for maturation/activation and antigen presentation as those from healthy subjects.
Tanoue S, Chang LY, Li Y, Kaplan DE. Tanoue S, et al. Cell Immunol. 2015 May;295(1):36-45. doi: 10.1016/j.cellimm.2015.02.008. Epub 2015 Feb 25. Cell Immunol. 2015. PMID: 25734547 Free PMC article. - Recombinant Salmonella-based 4-1BBL vaccine enhances T cell immunity and inhibits the development of colorectal cancer in rats: in vivo effects of vaccine containing 4-1BBL.
Ye J, Li L, Zhang Y, Zhang X, Ren D, Chen W. Ye J, et al. J Biomed Sci. 2013 Feb 17;20(1):8. doi: 10.1186/1423-0127-20-8. J Biomed Sci. 2013. PMID: 23413971 Free PMC article. - 4-1BB agonism: adding the accelerator to cancer immunotherapy.
Chester C, Ambulkar S, Kohrt HE. Chester C, et al. Cancer Immunol Immunother. 2016 Oct;65(10):1243-8. doi: 10.1007/s00262-016-1829-2. Epub 2016 Mar 31. Cancer Immunol Immunother. 2016. PMID: 27034234 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials