Epigenetic regulation of protein tyrosine phosphatases: potential molecular targets for cancer therapy - PubMed (original) (raw)

Review

Epigenetic regulation of protein tyrosine phosphatases: potential molecular targets for cancer therapy

Samson T Jacob et al. Cancer Gene Ther. 2005 Aug.

Abstract

Promoter methylation-mediated silencing is a hallmark of many established tumor suppressor genes. This review focuses on the methylation and suppression of a receptor-type tyrosine phosphatase gene, PTPRO, in a variety of solid and liquid tumors. In addition, PTPRO exhibits many other characteristics of a bona fide tumor suppressor. Reactivation of genes silenced by methylation using inhibitors of DNA methyltransferases and histone deacetylases, and the potential application of PTPRO as a molecular target for cancer therapy have been discussed.

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Figures

Figure 1

Protein isoforms of PTPRO. The full-length and truncated forms of PTPRO differ mainly with respect to their extracellular domains (fibronectin type III repeats). Each of these forms gives rise to two isoforms that are products of alternatively spliced transcripts, that is, by splicing of E17.

Figure 2

Schematic representation of the PTPRO gene.

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Epigenetic regulation of protein tyrosine phosphatases: potential molecular targets for cancer therapy - PubMed (original) (raw)