The REF-1 family of bHLH transcription factors pattern C. elegans embryos through Notch-dependent and Notch-independent pathways - PubMed (original) (raw)
Comparative Study
The REF-1 family of bHLH transcription factors pattern C. elegans embryos through Notch-dependent and Notch-independent pathways
Alexandre Neves et al. Dev Cell. 2005 Jun.
Free article
Abstract
Much of the patterning of early C. elegans embryos involves a series of Notch interactions that occur in rapid succession and have distinct outcomes; however, none of the targets for these interactions have been identified. We show that the REF-1 family of bHLH transcription factors is a major target of Notch signaling in all these interactions and that most examples of Notch-mediated transcriptional repression can be attributed to REF-1 activities. The REF-1 family is expressed and has similar functions in both Notch-dependent and Notch-independent pathways, and this dual mode of deployment is used repeatedly to pattern the embryo. REF-1 proteins are unusual in that they contain two different bHLH domains and lack the distinguishing characteristics of Hairy/Enhancer of Split (HES) bHLH proteins that are Notch targets in other systems. Our results show that the highly divergent REF-1 proteins are nonetheless HES-like bHLH effectors of Notch signaling.
Similar articles
- Regulation of neuronal lineage decisions by the HES-related bHLH protein REF-1.
Lanjuin A, Claggett J, Shibuya M, Hunter CP, Sengupta P. Lanjuin A, et al. Dev Biol. 2006 Feb 1;290(1):139-51. doi: 10.1016/j.ydbio.2005.11.018. Epub 2005 Dec 22. Dev Biol. 2006. PMID: 16376329 - Notch signaling in the C. elegans embryo.
Priess JR. Priess JR. WormBook. 2005 Jun 25:1-16. doi: 10.1895/wormbook.1.4.1. WormBook. 2005. PMID: 18050407 Free PMC article. Review. - Identification and expression of a novel family of bHLH cDNAs related to Drosophila hairy and enhancer of split.
Kokubo H, Lun Y, Johnson RL. Kokubo H, et al. Biochem Biophys Res Commun. 1999 Jul 5;260(2):459-65. doi: 10.1006/bbrc.1999.0880. Biochem Biophys Res Commun. 1999. PMID: 10403790 - The DM domain protein MAB-3 promotes sex-specific neurogenesis in C. elegans by regulating bHLH proteins.
Ross JM, Kalis AK, Murphy MW, Zarkower D. Ross JM, et al. Dev Cell. 2005 Jun;8(6):881-92. doi: 10.1016/j.devcel.2005.03.017. Dev Cell. 2005. PMID: 15935777
Cited by
- Neurogenesis in Caenorhabditis elegans.
Poole RJ, Flames N, Cochella L. Poole RJ, et al. Genetics. 2024 Oct 7;228(2):iyae116. doi: 10.1093/genetics/iyae116. Genetics. 2024. PMID: 39167071 Free PMC article. Review. - A developmental pathway for epithelial-to-motoneuron transformation in C. elegans.
Rashid A, Tevlin M, Lu Y, Shaham S. Rashid A, et al. Cell Rep. 2022 Sep 27;40(13):111414. doi: 10.1016/j.celrep.2022.111414. Cell Rep. 2022. PMID: 36170838 Free PMC article. - pop-1/TCF, ref-2/ZIC and T-box factors regulate the development of anterior cells in the C. elegans embryo.
Rumley JD, Preston EA, Cook D, Peng FL, Zacharias AL, Wu L, Jileaeva I, Murray JI. Rumley JD, et al. Dev Biol. 2022 Sep;489:34-46. doi: 10.1016/j.ydbio.2022.05.019. Epub 2022 May 31. Dev Biol. 2022. PMID: 35660370 Free PMC article. - A 4D single-cell protein atlas of transcription factors delineates spatiotemporal patterning during embryogenesis.
Ma X, Zhao Z, Xiao L, Xu W, Kou Y, Zhang Y, Wu G, Wang Y, Du Z. Ma X, et al. Nat Methods. 2021 Aug;18(8):893-902. doi: 10.1038/s41592-021-01216-1. Epub 2021 Jul 26. Nat Methods. 2021. PMID: 34312566 - Epithelial morphogenesis, tubulogenesis and forces in organogenesis.
Shaye DD, Soto MC. Shaye DD, et al. Curr Top Dev Biol. 2021;144:161-214. doi: 10.1016/bs.ctdb.2020.12.012. Epub 2021 Feb 8. Curr Top Dev Biol. 2021. PMID: 33992152 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous