The insulin-like growth factor system and colorectal cancer: clinical and experimental evidence - PubMed (original) (raw)

Review

The insulin-like growth factor system and colorectal cancer: clinical and experimental evidence

M Davies et al. Int J Colorectal Dis. 2006 Apr.

Abstract

Objective: The aim of this review is to clarify the involvement of the insulin-like growth factor (IGF) system in the development of colorectal malignancy.

Materials and methods: Medline searches were used to identify key articles relating the IGF system with the development of colorectal cancer.

Results: The IGF system has been linked to colorectal malignancy by a convergence of data from epidemiological, clinical and laboratory-based sources.

Conclusion: Further work is needed to characterise the IGF system expression in the colon. Such clarification could lead to the identification of targets that can be manipulated for clinical advantage.

PubMed Disclaimer

References

1. 1. Int J Cancer. 2003 Dec 20;107(6):873-7 -PubMed
2. 1. Carcinogenesis. 2003 Mar;24(3):393-401 -PubMed
3. 1. Cancer Res. 1996 Feb 1;56(3):523-6 -PubMed
4. 1. J Endocrinol. 2003 Dec;179(3):405-15 -PubMed
5. 1. J Clin Endocrinol Metab. 1995 Nov;80(11):3223-6 -PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Springer

• Medical

  • MedlinePlus Health Information