SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells - PubMed (original) (raw)
Comparative Study
. 2005 Jul 1;121(7):1109-21.
doi: 10.1016/j.cell.2005.05.026.
Affiliations
- PMID: 15989959
- DOI: 10.1016/j.cell.2005.05.026
Free article
Comparative Study
SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells
Mark J Kiel et al. Cell. 2005.
Free article
Abstract
To improve our ability to identify hematopoietic stem cells (HSCs) and their localization in vivo, we compared the gene expression profiles of highly purified HSCs and non-self-renewing multipotent hematopoietic progenitors (MPPs). Cell surface receptors of the SLAM family, including CD150, CD244, and CD48, were differentially expressed among functionally distinct progenitors. HSCs were highly purified as CD150(+)CD244(-)CD48(-) cells while MPPs were CD244(+)CD150(-)CD48(-) and most restricted progenitors were CD48(+)CD244(+)CD150(-). The primitiveness of hematopoietic progenitors could thus be predicted based on the combination of SLAM family members they expressed. This is the first family of receptors whose combinatorial expression precisely distinguishes stem and progenitor cells. The ability to purify HSCs based on a simple combination of SLAM receptors allowed us to identify HSCs in tissue sections. Many HSCs were associated with sinusoidal endothelium in spleen and bone marrow, though some HSCs were associated with endosteum. HSCs thus occupy multiple niches, including sinusoidal endothelium in diverse tissues.
Comment in
- Stem cell grand SLAM.
Wagers AJ. Wagers AJ. Cell. 2005 Jul 1;121(7):967-70. doi: 10.1016/j.cell.2005.06.017. Cell. 2005. PMID: 15989946 Review.
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