Effect of photic stimulation on human visual cortex lactate and phosphates using 1H and 31P magnetic resonance spectroscopy - PubMed (original) (raw)
Effect of photic stimulation on human visual cortex lactate and phosphates using 1H and 31P magnetic resonance spectroscopy
D Sappey-Marinier et al. J Cereb Blood Flow Metab. 1992 Jul.
Abstract
Previous animal and human studies showed that photic stimulation (PS) increased cerebral blood flow and glucose uptake much more than oxygen consumption, suggesting selective activation of anaerobic glycolysis. In the present studies, image-guided 1H and 31P magnetic resonance spectroscopy (MRS) was used to monitor the changes in lactate and high-energy phosphate concentrations produced by PS of visual cortex in six normal volunteers. PS initially produced a significant rise (to 250% of control, p less than 0.01) in visual cortex lactate during the first 6.4 min of PS, followed by a significant decline (p = 0.01) as PS continued. The PCr/Pi ratios decreased significantly from control values during the first 12.8 min of PS (p less than 0.05), and the pH was slightly increased. The positive P100 deflection of the visual evoked potential recorded between 100 and 172 ms after the strobe was significantly decreased from control at 12.8 min of PS (p less than 0.05). The finding that PS caused decreased PCr/Pi is consistent with the view that increased brain activity stimulated ATPase, causing a rise in ADP that shifted the creatine kinase reaction in the direction of ATP synthesis. The rise in lactate together with an increase in pH suggest that intracellular alkalosis, caused by the shift of creatine kinase, selectively stimulated glycolysis.
Similar articles
- Cerebral metabolism in experimental hydrocephalus: an in vivo 1H and 31P magnetic resonance spectroscopy study.
Braun KP, van Eijsden P, Vandertop WP, de Graaf RA, Gooskens RH, Tulleken KA, Nicolay K. Braun KP, et al. J Neurosurg. 1999 Oct;91(4):660-8. doi: 10.3171/jns.1999.91.4.0660. J Neurosurg. 1999. PMID: 10507389 - What the clinician can learn from MRS lactate measurements.
Prichard JW. Prichard JW. NMR Biomed. 1991 Apr;4(2):99-102. doi: 10.1002/nbm.1940040212. NMR Biomed. 1991. PMID: 1859788 Review. - Whole organ metabolism studied by NMR.
Gadian DG. Gadian DG. Annu Rev Biophys Bioeng. 1983;12:69-89. doi: 10.1146/annurev.bb.12.060183.000441. Annu Rev Biophys Bioeng. 1983. PMID: 6347045 Review. No abstract available.
Cited by
- Excitability Changes in Occipital Cortex After Continuous Theta-Burst Stimulation.
Aghamirzayeva K, Temuçin ÇM, Yıldız FG. Aghamirzayeva K, et al. Noro Psikiyatr Ars. 2023 Aug 23;67(3):228-234. doi: 10.29399/npa.28431. eCollection 2024. Noro Psikiyatr Ars. 2023. PMID: 39258130 Free PMC article. - Effectiveness of brainwave entrainment on pre-operative fear and anxiety in pediatric dental patients: a randomized controlled trial.
Shehani F, Samuel V, Kavitha R, Mani R. Shehani F, et al. Eur Arch Paediatr Dent. 2024 Aug;25(4):577-587. doi: 10.1007/s40368-024-00921-7. Epub 2024 Jul 9. Eur Arch Paediatr Dent. 2024. PMID: 38982009 Clinical Trial. - Functional Magnetic Resonance Spectroscopy of Prolonged Motor Activation using Conventional and Spectral GLM Analyses.
Morelli M, Dudzikowska K, Deelchand DK, Quinn AJ, Mullins PG, Apps MAJ, Wilson M. Morelli M, et al. bioRxiv [Preprint]. 2024 May 15:2024.05.15.594270. doi: 10.1101/2024.05.15.594270. bioRxiv. 2024. PMID: 38798416 Free PMC article. Preprint. - Effectiveness of Preoperative Alpha Wave Entrainment in Pediatric Dental Patients: A Randomized Controlled Trial.
Shehani A F, Samuel A V, Ramar K, Mani R. Shehani A F, et al. Cureus. 2024 May 12;16(5):e60154. doi: 10.7759/cureus.60154. eCollection 2024 May. Cureus. 2024. PMID: 38736759 Free PMC article. - Frequency-dependent dynamics of steady-state visual evoked potentials under sustained flicker stimulation.
Łabęcki M, Nowicka MM, Wróbel A, Suffczynski P. Łabęcki M, et al. Sci Rep. 2024 Apr 23;14(1):9281. doi: 10.1038/s41598-024-59770-5. Sci Rep. 2024. PMID: 38654008 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous