Co-localization of TRPV1-expressing nerve fibers with calcitonin-gene-related peptide and substance P in fundus of rat stomach - PubMed (original) (raw)

Co-localization of TRPV1-expressing nerve fibers with calcitonin-gene-related peptide and substance P in fundus of rat stomach

Syunji Horie et al. Inflammopharmacology. 2005.

Abstract

The localization of vanilloid receptor TRPV1 was studied in rat gastric fundus by an immunohistochemical technique. Numerous TRPV1-immunoreactive nerve fibers were found around arterioles in the submucosal layer. A large number of the nerve fibers were also seen in the smooth muscle layer and in the myenteric nerve plexus, but the cell bodies could not be found. TRPV1 nerve fibers within the circular muscle layers were running parallel to the muscle fibers. Virtually all TRPV1 axons were immunoreactive for calcitonin-gene-related peptide (CGRP), with particularly extensive double labeling seen in axons of the submucosa around blood vessels. TRPV1 nerve fibers containing substance P were found running in longitudinal muscle and circular muscle. The TRPV1 axons seem to be predominantly extrinsic and contain CGRP and substance P in gastric fundus. TRPV1 neurons are thought to be sensory afferent neurons that operate to maintain gastric motility and blood flow.

PubMed Disclaimer

Similar articles

• Distribution of transient receptor potential vanilloid 1 channel-expressing nerve fibers in mouse rectal and colonic enteric nervous system: relationship to peptidergic and nitrergic neurons.
  Matsumoto K, Hosoya T, Tashima K, Namiki T, Murayama T, Horie S. Matsumoto K, et al. Neuroscience. 2011 Jan 13;172:518-34. doi: 10.1016/j.neuroscience.2010.10.024. Epub 2010 Oct 15. Neuroscience. 2011. PMID: 20951772
• Immunohistochemical co-localization of transient receptor potential vanilloid (TRPV)1 and sensory neuropeptides in the guinea-pig respiratory system.
  Watanabe N, Horie S, Michael GJ, Keir S, Spina D, Page CP, Priestley JV. Watanabe N, et al. Neuroscience. 2006 Sep 1;141(3):1533-43. doi: 10.1016/j.neuroscience.2006.04.073. Epub 2006 Jun 12. Neuroscience. 2006. PMID: 16765524
• [Gastrointestinal Spice Sensors and Their Functions].
  Horie S, Tashima K, Matsumoto K. Horie S, et al. Yakugaku Zasshi. 2018;138(8):1003-1009. doi: 10.1248/yakushi.17-00048-1. Yakugaku Zasshi. 2018. PMID: 30068839 Review. Japanese.
• Occurrence and distribution of substance P- and CGRP-containing nerve fibers in gastric mucosa: species differences.
  Sundler F, Ekblad E, Håkanson R. Sundler F, et al. Adv Exp Med Biol. 1991;298:29-37. doi: 10.1007/978-1-4899-0744-8_3. Adv Exp Med Biol. 1991. PMID: 1719780 Review. No abstract available.

Cited by

• Glial cell line-derived neurotrophic factor family ligands enhance capsaicin-stimulated release of calcitonin gene-related peptide from sensory neurons.
  Schmutzler BS, Roy S, Hingtgen CM. Schmutzler BS, et al. Neuroscience. 2009 Jun 16;161(1):148-56. doi: 10.1016/j.neuroscience.2009.03.006. Epub 2009 Mar 11. Neuroscience. 2009. PMID: 19285119 Free PMC article.
• TRP channel functions in the gastrointestinal tract.
  Yu X, Yu M, Liu Y, Yu S. Yu X, et al. Semin Immunopathol. 2016 May;38(3):385-96. doi: 10.1007/s00281-015-0528-y. Epub 2015 Oct 12. Semin Immunopathol. 2016. PMID: 26459157 Review.
• Topographical organization and morphology of substance P (SP)-immunoreactive axons in the whole stomach of mice.
  Ma J, Mistareehi A, Madas J, Kwiat AM, Bendowski K, Nguyen D, Chen J, Li DP, B Furness J, L Powley T, Cheng ZJ. Ma J, et al. J Comp Neurol. 2023 Feb;531(2):188-216. doi: 10.1002/cne.25386. Epub 2022 Nov 17. J Comp Neurol. 2023. PMID: 36385363 Free PMC article.
• Role of visceral afferent neurons in mucosal inflammation and defense.
  Holzer P. Holzer P. Curr Opin Pharmacol. 2007 Dec;7(6):563-9. doi: 10.1016/j.coph.2007.09.004. Epub 2007 Oct 29. Curr Opin Pharmacol. 2007. PMID: 18029228 Free PMC article. Review.
• The role of gastrointestinal vagal afferent fibres in obesity.
  Kentish SJ, Page AJ. Kentish SJ, et al. J Physiol. 2015 Feb 15;593(4):775-86. doi: 10.1113/jphysiol.2014.278226. Epub 2014 Dec 23. J Physiol. 2015. PMID: 25433079 Free PMC article. Review.

References

1. 1. Neuron. 1998 Sep;21(3):531-43 - PubMed
2. 1. Neuroscience. 1988 Apr;25(1):181-93 - PubMed
3. 1. Cell Mol Life Sci. 2000 Apr;57(4):579-88 - PubMed
4. 1. Eur J Pharmacol. 1989 Mar 14;162(1):29-36 - PubMed
5. 1. Scand J Gastroenterol. 2004 Apr;39(4):303-12 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Ovid Technologies, Inc.

• Research Materials

  • NCI CPTC Antibody Characterization Program