KAI1/CD82, a tumor metastasis suppressor - PubMed (original) (raw)

Review

. 2006 Aug 28;240(2):183-94.

doi: 10.1016/j.canlet.2005.08.018. Epub 2005 Nov 2.

Affiliations

• PMID: 16260083
• DOI: 10.1016/j.canlet.2005.08.018

Review

KAI1/CD82, a tumor metastasis suppressor

Wei M Liu et al. Cancer Lett. 2006.

Abstract

Tetraspanin KAI1/CD82 is a wide-spectrum tumor metastasis suppressor. KAI1/CD82 suppresses tumor metastasis by primarily inhibiting cancer cell motility and invasiveness. In tetraspanin-enriched microdomain, KAI1/CD82 associates with the proteins important for cell migration such as cell adhesion molecule, growth factor receptor, and signaling molecule. Likely, KAI1/CD82 down-regulates the functions of these motility-related proteins to inhibit cell migration. The loss of KAI1/CD82 expression in invasive and metastatic cancers is due to a complex, epigenetic mechanism that probably involves transcription factors such as NFkappaB, p53, and beta-catenin.

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