The C-terminal activating region 2 of the Epstein-Barr virus-encoded latent membrane protein 1 activates NF-kappaB through TRAF6 and TAK1 - PubMed (original) (raw)
. 2006 Jan 27;281(4):2162-9.
doi: 10.1074/jbc.M505903200. Epub 2005 Nov 8.
Affiliations
- PMID: 16280329
- DOI: 10.1074/jbc.M505903200
Free article
The C-terminal activating region 2 of the Epstein-Barr virus-encoded latent membrane protein 1 activates NF-kappaB through TRAF6 and TAK1
Liming Wu et al. J Biol Chem. 2006.
Free article
Abstract
Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP1) is oncogenic and indispensable for EBV-mediated B cell transformation. LMP1 is capable of activating several intracellular signaling pathways including the NF-kappaB pathway, which contributes to the EBV-mediated cell transformation. Two regions in the cytoplasmic carboxyl tail of LMP1, namely C-terminal activating regions 1 and 2 (CTAR1 and CTAR2), are responsible for NF-kappaB activation, with CTAR2 being the main NF-kappaB activator. Although the CTAR1-mediated NF-kappaB activation was previously shown to be TRAF3-dependent, we showed here that the CTAR2-mediated NF-kappaB activation is mainly TRAF6-dependent but TRAF2/5-independent. In contrast to the interleukin-1 receptor/toll-like receptor-mediated NF-kappaB pathways, the CTAR2-mediated NF-kappaB pathway does not require MyD88, IRAK1, or IRAK4 for TRAF6 engagement. Furthermore, we showed that TAK1 is required for NF-kappaB activation by LMP1. Thus, LMP1 utilizes two distinct pathways to activate NF-kappaB: a major one through CTAR2/TRAF6/TAK1/IKKbeta (canonical pathway) and a minor one through CTAR1/TRAF3/NIK/IKKalpha (noncanonical pathway).
Similar articles
- Roles of TRAF2 and TRAF3 in Epstein-Barr virus latent membrane protein 1-induced alternative NF-kappaB activation.
Song YJ, Kang MS. Song YJ, et al. Virus Genes. 2010 Oct;41(2):174-80. doi: 10.1007/s11262-010-0505-4. Epub 2010 Jun 29. Virus Genes. 2010. PMID: 20585848 - Epstein-Barr virus-encoded latent membrane protein 1 activates the JNK pathway through its extreme C terminus via a mechanism involving TRADD and TRAF2.
Eliopoulos AG, Blake SM, Floettmann JE, Rowe M, Young LS. Eliopoulos AG, et al. J Virol. 1999 Feb;73(2):1023-35. doi: 10.1128/JVI.73.2.1023-1035.1999. J Virol. 1999. PMID: 9882303 Free PMC article. - LMP1 TRAFficking activates growth and survival pathways.
Soni V, Cahir-McFarland E, Kieff E. Soni V, et al. Adv Exp Med Biol. 2007;597:173-87. doi: 10.1007/978-0-387-70630-6_14. Adv Exp Med Biol. 2007. PMID: 17633026 Review. - NF-κB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1.
Ersing I, Bernhardt K, Gewurz BE. Ersing I, et al. Viruses. 2013 Jun 21;5(6):1587-606. doi: 10.3390/v5061587. Viruses. 2013. PMID: 23793113 Free PMC article. Review.
Cited by
- Epstein-Barr virus: the mastermind of immune chaos.
Silva JM, Alves CEC, Pontes GS. Silva JM, et al. Front Immunol. 2024 Feb 7;15:1297994. doi: 10.3389/fimmu.2024.1297994. eCollection 2024. Front Immunol. 2024. PMID: 38384471 Free PMC article. Review. - Epstein-Barr virus-driven B cell lymphoma mediated by a direct LMP1-TRAF6 complex.
Giehler F, Ostertag MS, Sommermann T, Weidl D, Sterz KR, Kutz H, Moosmann A, Feller SM, Geerlof A, Biesinger B, Popowicz GM, Kirchmair J, Kieser A. Giehler F, et al. Nat Commun. 2024 Jan 10;15(1):414. doi: 10.1038/s41467-023-44455-w. Nat Commun. 2024. PMID: 38195569 Free PMC article. - Pathogenesis and therapeutic implications of EBV-associated epithelial cancers.
Low YH, Loh CJL, Peh DYY, Chu AJM, Han S, Toh HC. Low YH, et al. Front Oncol. 2023 Oct 2;13:1202117. doi: 10.3389/fonc.2023.1202117. eCollection 2023. Front Oncol. 2023. PMID: 37901329 Free PMC article. Review. - Comprehensive insight into altered host cell-signaling cascades upon Helicobacter pylori and Epstein-Barr virus infections in cancer.
Kashyap D, Rele S, Bagde PH, Saini V, Chatterjee D, Jain AK, Pandey RK, Jha HC. Kashyap D, et al. Arch Microbiol. 2023 Jun 13;205(7):262. doi: 10.1007/s00203-023-03598-6. Arch Microbiol. 2023. PMID: 37310490 Review. - The microdissected gene expression landscape of nasopharyngeal cancer reveals vulnerabilities in FGF and noncanonical NF-κB signaling.
Tay JK, Zhu C, Shin JH, Zhu SX, Varma S, Foley JW, Vennam S, Yip YL, Goh CK, Wang Y, Loh KS, Tsao SW, Le QT, Sunwoo JB, West RB. Tay JK, et al. Sci Adv. 2022 Apr 8;8(14):eabh2445. doi: 10.1126/sciadv.abh2445. Epub 2022 Apr 8. Sci Adv. 2022. PMID: 35394843 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous