A poxvirus-encoded pyrin domain protein interacts with ASC-1 to inhibit host inflammatory and apoptotic responses to infection - PubMed (original) (raw)

Comparative Study

A poxvirus-encoded pyrin domain protein interacts with ASC-1 to inhibit host inflammatory and apoptotic responses to infection

James B Johnston et al. Immunity. 2005 Dec.

Free article

Erratum in

Immunity. 2006 Oct;25(4):687. Ricuttio, Dan [corrected to Ricciuto, Dan]

Abstract

Proinflammatory caspases play an essential role in innate immune responses to infection by regulating the cleavage and activation of proinflammatory cytokines. Activation of these enzymes requires the assembly of an intracellular molecular platform, termed the inflammasome, which is comprised of members of the pyrin domain (PYD)-containing superfamily of apoptosis and inflammation-regulatory proteins. We report here the identification and characterization of a poxvirus-encoded PYD-containing protein that interacts with the ASC-1 component of the inflammasome and inhibits caspase-1 activation and the processing of IL-1beta and IL-18 induced by diverse stimuli. Knockout viruses that do not express this protein are unable to productively infect monocytes and lymphocytes due to an abortive phenotype and are markedly attenuated in susceptible hosts due to decreased virus dissemination and enhanced inflammatory responses at sites of infection. Thus, modulation of inflammasome function constitutes an important immunomodulatory strategy employed by poxviruses to circumvent host antiviral responses.

PubMed Disclaimer

Comment in

Poxviruses aren't stuPYD.
Benedict CA, Ware CF. Benedict CA, et al. Immunity. 2005 Dec;23(6):553-5. doi: 10.1016/j.immuni.2005.11.008. Immunity. 2005. PMID: 16356854

Cited by

Porphyromonas gingivalis mediates inflammasome repression in polymicrobial cultures through a novel mechanism involving reduced endocytosis.
Taxman DJ, Swanson KV, Broglie PM, Wen H, Holley-Guthrie E, Huang MT, Callaway JB, Eitas TK, Duncan JA, Ting JP. Taxman DJ, et al. J Biol Chem. 2012 Sep 21;287(39):32791-9. doi: 10.1074/jbc.M112.401737. Epub 2012 Jul 26. J Biol Chem. 2012. PMID: 22843689 Free PMC article.
Roles of Inflammasomes in Epstein-Barr Virus-Associated Nasopharyngeal Cancer.
Looi CK, Hii LW, Chung FF, Mai CW, Lim WM, Leong CO. Looi CK, et al. Cancers (Basel). 2021 Apr 8;13(8):1786. doi: 10.3390/cancers13081786. Cancers (Basel). 2021. PMID: 33918087 Free PMC article. Review.
IFI16 is an innate immune sensor for intracellular DNA.
Unterholzner L, Keating SE, Baran M, Horan KA, Jensen SB, Sharma S, Sirois CM, Jin T, Latz E, Xiao TS, Fitzgerald KA, Paludan SR, Bowie AG. Unterholzner L, et al. Nat Immunol. 2010 Nov;11(11):997-1004. doi: 10.1038/ni.1932. Epub 2010 Oct 3. Nat Immunol. 2010. PMID: 20890285 Free PMC article.
Autoinflammatory disease reloaded: a clinical perspective.
Kastner DL, Aksentijevich I, Goldbach-Mansky R. Kastner DL, et al. Cell. 2010 Mar 19;140(6):784-90. doi: 10.1016/j.cell.2010.03.002. Cell. 2010. PMID: 20303869 Free PMC article.
Revisiting Regulated Cell Death Responses in Viral Infections.
Rex DAB, Keshava Prasad TS, Kandasamy RK. Rex DAB, et al. Int J Mol Sci. 2022 Jun 24;23(13):7023. doi: 10.3390/ijms23137023. Int J Mol Sci. 2022. PMID: 35806033 Free PMC article. Review.

A poxvirus-encoded pyrin domain protein interacts with ASC-1 to inhibit host inflammatory and apoptotic responses to infection - PubMed (original) (raw)