Vanilloid receptor (TRPV1)-deficient mice show increased susceptibility to dinitrobenzene sulfonic acid induced colitis - PubMed (original) (raw)

Vanilloid receptor (TRPV1)-deficient mice show increased susceptibility to dinitrobenzene sulfonic acid induced colitis

F Massa et al. J Mol Med (Berl). 2006 Feb.

Abstract

In the human colon, vanilloid receptor TRPV1 is overexpressed both in afferent nerve terminals and in epithelial cells during inflammation. In the past years, pharmacological experiments using TRPV1 agonists and antagonists revealed that TRPV1 receptors may play proinflammatory and protective roles in the gastrointestinal tract. Here, we applied a genetic approach to define the role of TRPV1 and analyzed the effects of dinitrobenzene sulfonic acid (DNBS)-induced colitis in TRPV1-deficient (TRPV1-/-) mice. Intrarectal infusion of DNBS induced increased inflammation in TRPV1-/- mice compared to wild-type littermates (TRPV1+/+) as evaluated by macroscopic scoring and myeloperoxidase assays. This finding indicates that TRPV1 receptors are required for the protection within sensory pathways that regulate the response following the initiation of colonic inflammation. Electrophysiological recordings from circular smooth-muscle cells, performed 8 and 24 h after DNBS treatment, revealed strong spontaneous oscillatory action potentials in TRPV1-/- but not in TRPV1+/+ colons, indicating an early TRPV1-mediated control of inflammation-induced irritation of smooth-muscle activities. These unexpected results suggest that TRPV1 receptors mediate endogenous protection against experimentally induced colonic inflammation.

PubMed Disclaimer

Cited by

TRP channel functions in the gastrointestinal tract.
Yu X, Yu M, Liu Y, Yu S. Yu X, et al. Semin Immunopathol. 2016 May;38(3):385-96. doi: 10.1007/s00281-015-0528-y. Epub 2015 Oct 12. Semin Immunopathol. 2016. PMID: 26459157 Review.
TRP channels in the digestive system.
Holzer P. Holzer P. Curr Pharm Biotechnol. 2011 Jan 1;12(1):24-34. doi: 10.2174/138920111793937862. Curr Pharm Biotechnol. 2011. PMID: 20932260 Free PMC article. Review.
Upregulation of the transient receptor potential vanilloid 1 in colonic epithelium of patients with active inflammatory bowel disease.
Luo C, Wang Z, Mu J, Zhu M, Zhen Y, Zhang H. Luo C, et al. Int J Clin Exp Pathol. 2017 Nov 1;10(11):11335-11344. eCollection 2017. Int J Clin Exp Pathol. 2017. PMID: 31966488 Free PMC article.
Gain of Function of Ion Channel TRPV1 Exacerbates Experimental Colitis by Promoting Dendritic Cell Activation.
Duo L, Wu T, Ke Z, Hu L, Wang C, Teng G, Zhang W, Wang W, Ge Q, Yang Y, Dai Y. Duo L, et al. Mol Ther Nucleic Acids. 2020 Oct 14;22:924-936. doi: 10.1016/j.omtn.2020.10.006. eCollection 2020 Dec 4. Mol Ther Nucleic Acids. 2020. PMID: 33251043 Free PMC article.
Lack of transient receptor potential vanilloid 1 channel modulates the development of neurogenic bladder dysfunction induced by cross-sensitization in afferent pathways.
Lei Q, Pan XQ, Villamor AN, Asfaw TS, Chang S, Zderic SA, Malykhina AP. Lei Q, et al. J Neuroinflammation. 2013 Jan 11;10:3. doi: 10.1186/1742-2094-10-3. J Neuroinflammation. 2013. PMID: 23305398 Free PMC article.

References

1. Br J Pharmacol. 2004 Apr;141(8):1313-20 - PubMed
1. Peptides. 2001 Sep;22(9):1439-46 - PubMed
1. J Clin Invest. 2004 Apr;113(8):1202-9 - PubMed
1. J Pharmacol Exp Ther. 2003 Feb;304(2):713-22 - PubMed
1. Eur J Biochem. 2004 May;271(10 ):1827-34 - PubMed

Vanilloid receptor (TRPV1)-deficient mice show increased susceptibility to dinitrobenzene sulfonic acid induced colitis - PubMed (original) (raw)