Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer - PubMed (original) (raw)
Review
doi: 10.1038/nrc1779.
Affiliations
- PMID: 16397526
- DOI: 10.1038/nrc1779
Free article
Review
Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer
Saverio Minucci et al. Nat Rev Cancer. 2006 Jan.
Free article
Abstract
Histone deacetylases (HDACs) are considered to be among the most promising targets in drug development for cancer therapy, and first-generation histone deacetylase inhibitors (HDACi) are currently being tested in phase I/II clinical trials. A wide-ranging knowledge of the role of HDACs in tumorigenesis, and of the action of HDACi, has been achieved. However, several basic aspects are not yet fully understood. Investigating these aspects in the context of what we now understand about HDACi action both in vitro and in vivo will further improve the design of optimized clinical protocols.
Similar articles
- Histone deacetylase inhibitors as a new weapon in the arsenal of differentiation therapies of cancer.
Botrugno OA, Santoro F, Minucci S. Botrugno OA, et al. Cancer Lett. 2009 Aug 8;280(2):134-44. doi: 10.1016/j.canlet.2009.02.027. Epub 2009 Apr 2. Cancer Lett. 2009. PMID: 19345000 Review. - Histone deacetylase inhibitors for epigenetic therapy of cancer.
Monneret C. Monneret C. Anticancer Drugs. 2007 Apr;18(4):363-70. doi: 10.1097/CAD.0b013e328012a5db. Anticancer Drugs. 2007. PMID: 17351388 Review. - Histone deacetylase inhibitors: molecular mechanisms of action.
Xu WS, Parmigiani RB, Marks PA. Xu WS, et al. Oncogene. 2007 Aug 13;26(37):5541-52. doi: 10.1038/sj.onc.1210620. Oncogene. 2007. PMID: 17694093 Review. - Targeting histone deacetylase in cancer therapy.
Lin HY, Chen CS, Lin SP, Weng JR, Chen CS. Lin HY, et al. Med Res Rev. 2006 Jul;26(4):397-413. doi: 10.1002/med.20056. Med Res Rev. 2006. PMID: 16450343 Review. - Epi-drugs to fight cancer: from chemistry to cancer treatment, the road ahead.
Mai A, Altucci L. Mai A, et al. Int J Biochem Cell Biol. 2009 Jan;41(1):199-213. doi: 10.1016/j.biocel.2008.08.020. Epub 2008 Aug 22. Int J Biochem Cell Biol. 2009. PMID: 18790076 Review.
Cited by
- Inhibition of class I histone deacetylases unveils a mitochondrial signature and enhances oxidative metabolism in skeletal muscle and adipose tissue.
Galmozzi A, Mitro N, Ferrari A, Gers E, Gilardi F, Godio C, Cermenati G, Gualerzi A, Donetti E, Rotili D, Valente S, Guerrini U, Caruso D, Mai A, Saez E, De Fabiani E, Crestani M. Galmozzi A, et al. Diabetes. 2013 Mar;62(3):732-42. doi: 10.2337/db12-0548. Epub 2012 Oct 15. Diabetes. 2013. PMID: 23069623 Free PMC article. - Epimutational profile of hematologic malignancies as attractive target for new epigenetic therapies.
Fratta E, Montico B, Rizzo A, Colizzi F, Sigalotti L, Dolcetti R. Fratta E, et al. Oncotarget. 2016 Aug 30;7(35):57327-57350. doi: 10.18632/oncotarget.10033. Oncotarget. 2016. PMID: 27329599 Free PMC article. Review. - Expression of the class 1 histone deacetylases HDAC8 and 3 are associated with improved survival of patients with metastatic melanoma.
Wilmott JS, Colebatch AJ, Kakavand H, Shang P, Carlino MS, Thompson JF, Long GV, Scolyer RA, Hersey P. Wilmott JS, et al. Mod Pathol. 2015 Jul;28(7):884-94. doi: 10.1038/modpathol.2015.34. Epub 2015 Apr 3. Mod Pathol. 2015. PMID: 25836739 - Modular Development of Enzyme-Activatable Proteolysis Targeting Chimeras for Selective Protein Degradation and Cancer Targeting.
Chen Y, Zhang L, Fang L, Chen C, Zhang D, Peng T. Chen Y, et al. JACS Au. 2024 May 16;4(7):2564-2577. doi: 10.1021/jacsau.4c00298. eCollection 2024 Jul 22. JACS Au. 2024. PMID: 39055140 Free PMC article. - A Synthetic Cell-Penetrating Heparin-Binding Peptide Derived from BMP4 with Anti-Inflammatory and Chondrogenic Functions for the Treatment of Arthritis.
Choi DH, Lee D, Jo BS, Park KS, Lee KE, Choi JK, Park YJ, Lee JY, Park YS. Choi DH, et al. Int J Mol Sci. 2020 Jun 15;21(12):4251. doi: 10.3390/ijms21124251. Int J Mol Sci. 2020. PMID: 32549254 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources