Endothelial function in HIV-infected persons - PubMed (original) (raw)

. 2006 May 1;42(9):1325-32.

doi: 10.1086/503261. Epub 2006 Mar 31.

Affiliations

Endothelial function in HIV-infected persons

Anthony Solages et al. Clin Infect Dis. 2006.

Abstract

Background: Several reports have suggested an increased risk of coronary disease in human immunodeficiency virus (HIV)-infected patients receiving protease inhibitors (PIs). Impaired endothelium-dependent vasodilation is a putative surrogate marker of coronary atherosclerotic disease.

Methods: The present study evaluated the effect of HIV infection and antiretroviral treatment on endothelial vasomotor function, by assessing brachial artery flow-mediated dilation (FMD). A total of 75 HIV-infected patients were compared with 223 control subjects who were presumed to be HIV uninfected.

Results: HIV-infected patients had significantly impaired FMD, compared with control subjects (mean +/- SD, 7.3% +/- 4.4% vs. 11.1% +/- 6.3%; P < .0001). When adjustments were made for smoking status, sex, and body mass index, the difference between the 2 groups remained statistically significant (P < .01). In a cross-sectional analysis of the HIV-infected patients, we found significant associations between FMD and current injection drug use, hazardous drinking, HIV load, and alpha-high-density lipoprotein triglyceride levels, but not PI therapy. In a multivariate analysis, only current injection drug use and a lower alpha-high-density lipoprotein triglyceride level were significantly associated with FMD.

Conclusions: HIV-infected patients have significant impairment of endothelial function, and this impairment is worse among those with elevated levels of HIV replication, particularly injection drug users.

PubMed Disclaimer

Comment in

Similar articles

Cited by

References

    1. Centers for Disease Control and Prevention Update: trend in AIDS incidence, deaths, and prevalence-United States, 1996. MMWR Morb Mortal Wkly Rep. 1997;46:165–73. - PubMed
    1. Chaisson MA, Heffness J, Li W, Singh T. Decline in AIDS mortality by gender and race/ethnicity in New York City [abstract 550]. National HIV Prevention Conference.1999.
    1. Hogg RS, O’Shaughnessy MV, et al. Decline in deaths from AIDS due to new antiretrovirals. Lancet. 1997;349:1294. - PubMed
    1. Torres RA, Barr M, et al. Impact of combination therapy for HIV infection on inpatient census. N Engl J Med. 1997;336:1531–2. - PubMed
    1. Palella FJ, Delaney KM, Moorman AC, et al. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. N Engl J Med. 1998;338:853–60. - PubMed

Publication types

MeSH terms

Grants and funding

LinkOut - more resources