Adapalene gel, 0.1%, as maintenance therapy for acne vulgaris: a randomized, controlled, investigator-blind follow-up of a recent combination study - PubMed (original) (raw)
Randomized Controlled Trial
. 2006 May;142(5):597-602.
doi: 10.1001/archderm.142.5.597.
Affiliations
- PMID: 16702497
- DOI: 10.1001/archderm.142.5.597
Randomized Controlled Trial
Adapalene gel, 0.1%, as maintenance therapy for acne vulgaris: a randomized, controlled, investigator-blind follow-up of a recent combination study
Diane M Thiboutot et al. Arch Dermatol. 2006 May.
Abstract
Objective: To assess the maintenance effect of adapalene gel, 0.1%, relative to gel vehicle in subjects successfully treated in a previous 12-week study of adapalene-doxycycline, 100 mg, combination therapy.
Design: Multicenter, investigator-blind, randomized, controlled study.
Setting: Thirty-four US centers.
Subjects: A total of 253 subjects with severe acne vulgaris who showed at least moderate improvement from baseline (50% improvement from baseline) when treated with either adapalene plus doxycycline or doxycycline plus gel vehicle in a previous 12-week study.
Interventions: Subjects were randomized to receive adapalene gel, 0.1%, or gel vehicle once daily for 16 weeks.
Main outcome measures: Efficacy and safety criteria included maintenance rate (subjects maintaining at least 50% improvement in lesion counts from previous therapy), lesion counts (total, inflammatory, and noninflammatory), global severity assessment, cutaneous tolerability, and adverse events.
Results: Adapalene maintenance therapy resulted in significantly larger maintenance rates (75% vs 54%; P<.001) and significantly lower lesion counts (total [P = .005], inflammatory [P = .01], and noninflammatory [P = .02]) compared with gel vehicle. Adapalene was safe and well tolerated in this study. Conclusion This study demonstrates a clinical benefit of continued treatment with adapalene gel, 0.1%, as a maintenance therapy for acne.
Comment in
- Acne maintenance therapy: expanding the role of topical retinoids?
Zane LT. Zane LT. Arch Dermatol. 2006 May;142(5):638-40. doi: 10.1001/archderm.142.5.638. Arch Dermatol. 2006. PMID: 16702503 No abstract available.
Similar articles
- Daily treatment with adapalene gel 0.1% maintains initial improvement of acne vulgaris previously treated with oral lymecycline.
Alirezai M, George SA, Coutts I, Roseeuw DI, Hachem JP, Kerrouche N, Sidou F, Soto P. Alirezai M, et al. Eur J Dermatol. 2007 Jan-Feb;17(1):45-51. doi: 10.1684/ejd.2007.0188. Epub 2007 Feb 27. Eur J Dermatol. 2007. PMID: 17324827 Clinical Trial. - A 6-month maintenance therapy with adapalene-benzoyl peroxide gel prevents relapse and continuously improves efficacy among patients with severe acne vulgaris: results of a randomized controlled trial.
Poulin Y, Sanchez NP, Bucko A, Fowler J, Jarratt M, Kempers S, Kerrouche N, Dhuin JC, Kunynetz R. Poulin Y, et al. Br J Dermatol. 2011 Jun;164(6):1376-82. doi: 10.1111/j.1365-2133.2011.10344.x. Epub 2011 May 20. Br J Dermatol. 2011. PMID: 21457209 Clinical Trial. - A North American study of adapalene-benzoyl peroxide combination gel in the treatment of acne.
Gold LS, Tan J, Cruz-Santana A, Papp K, Poulin Y, Schlessinger J, Gidner J, Liu Y, Graeber M; Adapalene-BPO Study Group. Gold LS, et al. Cutis. 2009 Aug;84(2):110-6. Cutis. 2009. PMID: 19746769 Clinical Trial. - Adapalene 0.1%/benzoyl peroxide 2.5% gel: a review of its use in the treatment of acne vulgaris in patients aged ≥ 12 years.
Keating GM. Keating GM. Am J Clin Dermatol. 2011 Dec 1;12(6):407-20. doi: 10.2165/11208170-000000000-00000. Am J Clin Dermatol. 2011. PMID: 21967116 Review. - Spotlight on adapalene in acne vulgaris.
Waugh J, Noble S, Scott LJ. Waugh J, et al. Am J Clin Dermatol. 2004;5(5):369-71. doi: 10.2165/00128071-200405050-00014. Am J Clin Dermatol. 2004. PMID: 15554742 Review.
Cited by
- Oral Antibiotic Treatment Options for Acne Vulgaris.
Baldwin H. Baldwin H. J Clin Aesthet Dermatol. 2020 Sep;13(9):26-32. Epub 2020 Sep 1. J Clin Aesthet Dermatol. 2020. PMID: 33133338 Free PMC article. Review. - Trends in Office Visits for the Five Most Common Skin Diseases in the United States.
Grada A, Muddasani S, Fleischer AB Jr, Feldman SR, Peck GM. Grada A, et al. J Clin Aesthet Dermatol. 2022 May;15(5):E82-E86. J Clin Aesthet Dermatol. 2022. PMID: 35642232 Free PMC article. Review. - Acne vulgaris.
Purdy S, Deberker D. Purdy S, et al. BMJ Clin Evid. 2008 May 15;2008:1714. BMJ Clin Evid. 2008. PMID: 19450306 Free PMC article. Review. - Optimizing the use of topical retinoids in Asian acne patients.
See JA, Goh CL, Hayashi N, Suh DH, Casintahan FA. See JA, et al. J Dermatol. 2018 May;45(5):522-528. doi: 10.1111/1346-8138.14314. Epub 2018 Apr 3. J Dermatol. 2018. PMID: 29611225 Free PMC article. Review. - [Drug therapy of acne].
Ochsendorf FR, Degitz K. Ochsendorf FR, et al. Hautarzt. 2008 Jul;59(7):579-89; quiz 590. doi: 10.1007/s00105-008-1498-y. Hautarzt. 2008. PMID: 18535811 Review. German.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical