Cysteinyl leukotrienes: multi-functional mediators in allergic rhinitis - PubMed (original) (raw)

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Cysteinyl leukotrienes: multi-functional mediators in allergic rhinitis

M Peters-Golden et al. Clin Exp Allergy. 2006 Jun.

Abstract

Cysteinyl leukotrienes (CysLTs) are a family of inflammatory lipid mediators synthesized from arachidonic acid by a variety of cells, including mast cells, eosinophils, basophils, and macrophages. This article reviews the data for the role of CysLTs as multi-functional mediators in allergic rhinitis (AR). We review the evidence that: (1) CysLTs are released from inflammatory cells that participate in AR, (2) receptors for CysLTs are located in nasal tissue, (3) CysLTs are increased in patients with AR and are released following allergen exposure, (4) administration of CysLTs reproduces the symptoms of AR, (5) CysLTs play roles in the maturation, as well as tissue recruitment, of inflammatory cells, and (6) a complex inter-regulation between CysLTs and a variety of other inflammatory mediators exists.

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Figures

Fig. 1

Fig. 1

Cysteinyl leukotrienes (CysLTs) and the Inflammatory Events of Allergic Rhinitis. Crosslinking of immunoglobulin E with allergen initiates release of a variety of mediators from mast cells, including CysLTs. CysLTs play a role in hematopoiesis, cellular migration from bone marrow to the circulation, adhesion of inflammatory cells to the vascular endothelium, migration of cells to the nasal tissue, cell survival, and cellular activity enhancement.

Fig. 2

Fig. 2

Interactions between cysteinyl leukotrienes (CysLTs) and inflammatory mediators. (a) Studies have demonstrated bidirectional regulation of these mediators; i.e., activity of these mediators can be modulated by CysLTs and, in turn, these mediators can modulate CysLTs activity. (b) Studies have demonstrated that the activity of these mediators can be modulated by CysLTs. (c) Studies have demonstrated that these mediators can modulate activity of CysLTs.

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