Kruppel-like factor 2 regulates thymocyte and T-cell migration - PubMed (original) (raw)
. 2006 Jul 20;442(7100):299-302.
doi: 10.1038/nature04882.
Affiliations
- PMID: 16855590
- DOI: 10.1038/nature04882
Kruppel-like factor 2 regulates thymocyte and T-cell migration
Corey M Carlson et al. Nature. 2006.
Abstract
Mammalian Kruppel-like transcription factors are implicated in regulating terminal differentiation of several tissue types. Deficiency in Kruppel-like factor (KLF) 2 (also known as LKLF) leads to a massive loss of the peripheral T-cell pool, suggesting KLF2 regulates T-cell quiescence and survival. Here we show, however, that KLF2 is essential for T-cell trafficking. KLF2-deficient (Klf2-/-) thymocytes show impaired expression of several receptors required for thymocyte emigration and peripheral trafficking, including the sphingosine-1-phosphate (S1P) receptor S1P1, CD62L and beta7 integrin. Furthermore, KLF2 both binds and transactivates the promoter for S1P1--a receptor that is critical for thymocyte egress and recirculation through peripheral lymphoid organs. Our findings suggest that KLF2 serves to license mature T cells for trafficking from the thymus and recirculation through secondary lymphoid tissues.
Similar articles
- Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1.
Matloubian M, Lo CG, Cinamon G, Lesneski MJ, Xu Y, Brinkmann V, Allende ML, Proia RL, Cyster JG. Matloubian M, et al. Nature. 2004 Jan 22;427(6972):355-60. doi: 10.1038/nature02284. Nature. 2004. PMID: 14737169 - Kruppel-like factor 2 controls T cell trafficking by activating L-selectin (CD62L) and sphingosine-1-phosphate receptor 1 transcription.
Bai A, Hu H, Yeung M, Chen J. Bai A, et al. J Immunol. 2007 Jun 15;178(12):7632-9. doi: 10.4049/jimmunol.178.12.7632. J Immunol. 2007. PMID: 17548599 - Transcription factor KLF2 regulates the migration of naive T cells by restricting chemokine receptor expression patterns.
Sebzda E, Zou Z, Lee JS, Wang T, Kahn ML. Sebzda E, et al. Nat Immunol. 2008 Mar;9(3):292-300. doi: 10.1038/ni1565. Epub 2008 Feb 3. Nat Immunol. 2008. PMID: 18246069 - Thymic output: influence factors and molecular mechanism.
Jin R, Zhang J, Chen W. Jin R, et al. Cell Mol Immunol. 2006 Oct;3(5):341-50. Cell Mol Immunol. 2006. PMID: 17092431 Review. - Thymic emigration: sphingosine-1-phosphate receptor-1-dependent models and beyond.
Drennan MB, Elewaut D, Hogquist KA. Drennan MB, et al. Eur J Immunol. 2009 Apr;39(4):925-30. doi: 10.1002/eji.200838912. Eur J Immunol. 2009. PMID: 19224640 Review.
Cited by
- KLF2 determines the susceptibility of T cells to immunoregulatory NK cells.
Waggoner S, Cox A, Canaday L, Katko A, Feldman H, Warrick K, Tselikova A, Seelamneni H, Roskin K. Waggoner S, et al. Res Sq [Preprint]. 2024 Aug 30:rs.3.rs-4921081. doi: 10.21203/rs.3.rs-4921081/v1. Res Sq. 2024. PMID: 39257976 Free PMC article. Preprint. - Fate induction in CD8 CAR T cells through asymmetric cell division.
Lee CS, Chen S, Berry CT, Kelly AR, Herman PJ, Oh S, O'Connor RS, Payne AS, Ellebrecht CT. Lee CS, et al. Nature. 2024 Sep;633(8030):670-677. doi: 10.1038/s41586-024-07862-7. Epub 2024 Aug 28. Nature. 2024. PMID: 39198645 Free PMC article. - CD4+ T cells exhibit distinct transcriptional phenotypes in the lymph nodes and blood following mRNA vaccination in humans.
Borcherding N, Kim W, Quinn M, Han F, Zhou JQ, Sturtz AJ, Schmitz AJ, Lei T, Schattgen SA, Klebert MK, Suessen T, Middleton WD, Goss CW, Liu C, Crawford JC, Thomas PG, Teefey SA, Presti RM, O'Halloran JA, Turner JS, Ellebedy AH, Mudd PA. Borcherding N, et al. Nat Immunol. 2024 Sep;25(9):1731-1741. doi: 10.1038/s41590-024-01888-9. Epub 2024 Aug 20. Nat Immunol. 2024. PMID: 39164479 - Sphingosine-1-phosphate signaling regulates the ability of Müller glia to become neurogenic, proliferating progenitor-like cells.
Taylor O, DeGroff N, El-Hodiri H, Gao C, Fischer AJ. Taylor O, et al. bioRxiv [Preprint]. 2024 Sep 27:2024.08.06.606815. doi: 10.1101/2024.08.06.606815. bioRxiv. 2024. PMID: 39149287 Free PMC article. Preprint. - KMT2D regulates activation, localization, and integrin expression by T-cells.
Potter SJ, Zhang L, Kotliar M, Wu Y, Schafer C, Stefan K, Boukas L, Qu'd D, Bodamer O, Simpson BN, Barski A, Lindsley AW, Bjornsson HT. Potter SJ, et al. Front Immunol. 2024 May 3;15:1341745. doi: 10.3389/fimmu.2024.1341745. eCollection 2024. Front Immunol. 2024. PMID: 38765012 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases