IL-25 enhances allergic airway inflammation by amplifying a TH2 cell-dependent pathway in mice - PubMed (original) (raw)
. 2006 Sep;118(3):606-14.
doi: 10.1016/j.jaci.2006.04.051. Epub 2006 Jun 21.
Yuko Maezawa, Kei Ikeda, Shin-Ichiro Kagami, Masahiko Hatano, Yohei Seto, Akira Suto, Kotaro Suzuki, Norihiko Watanabe, Yasushi Saito, Takeshi Tokuhisa, Itsuo Iwamoto, Hiroshi Nakajima
Affiliations
- PMID: 16950278
- DOI: 10.1016/j.jaci.2006.04.051
IL-25 enhances allergic airway inflammation by amplifying a TH2 cell-dependent pathway in mice
Tomohiro Tamachi et al. J Allergy Clin Immunol. 2006 Sep.
Abstract
Background: A novel IL-17 family cytokine, IL-25, has been reported to induce IL-4, IL-5, and IL-13 production from undefined non-T/non-B cells and then induce T(H)2-type immune responses. However, the roles of IL-25 in inducing allergic airway inflammation remain unknown.
Objective: We sought to determine whether IL-25 is involved in causing allergic airway inflammation.
Methods: We examined the expression of IL-25 mRNA in the lungs of sensitized mice on antigen inhalation. We also examined the effect of IL-25 neutralization by soluble IL-25 receptor on antigen-induced airway inflammation. We then generated IL-25 transgenic mice that express IL-25 specifically in the lung under the control of the Clara cells-10-kd protein promoter and investigated the effect of enforced IL-25 expression on antigen-induced airway inflammation.
Results: IL-25 mRNA was expressed in the lungs of sensitized mice on antigen inhalation, and the neutralization of IL-25 by soluble IL-25 receptor decreased antigen-induced eosinophil and CD4(+) T-cell recruitment into the airways. The enforced expression of IL-25 in the lung itself failed to induce allergic airway inflammation, whereas the expression of IL-25 significantly enhanced antigen-induced T(H)2 cytokine production, eosinophil and CD4(+) T cell recruitment, and goblet cell hyperplasia in the airways. Moreover, IL-25-induced enhancement of allergic airway inflammation was inhibited by the depletion of CD4(+) T cells or by the absence of signal transducer and activator of transcription 6.
Conclusion: IL-25 enhances antigen-induced allergic airway inflammation by amplifying a T(H)2 cell-dependent pathway.
Clinical implications: IL-25 might be involved in the enhancement, prolongation, or both of T(H)2 cell-mediated allergic diseases, such as asthma.
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