CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease - PubMed (original) (raw)
. 2006 Nov;129(Pt 11):3035-41.
doi: 10.1093/brain/awl269. Epub 2006 Sep 29.
Affiliations
- PMID: 17012293
- DOI: 10.1093/brain/awl269
CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease
Katharina Buerger et al. Brain. 2006 Nov.
Abstract
Hyperphosphorylated tau protein (P-tau) in CSF is a core biomarker candidate of Alzheimer's disease. Hyperphosphorylation of tau is thought to lead to neurofibrillary changes, a neuropathological hallmark of this type of dementia. Currently, the question is unresolved whether CSF levels of P-tau reflect neurofibrillary changes within the brain of a patient with the illness. Twenty-six patients were included with intra-vitam CSF as well as post-mortem neuropathological data. In the CSF, P-tau phosphorylated at threonine 231 (P-tau231P) was analysed. Post-mortem, scores of neurofibrillary tangles (NFT) and neuritic plaques (NP) were assessed in frontal, temporal, parietal and hippocampal cortical areas. In the same cortical regions, load of hyperphosphorylated tau protein (HP-tau load) was determined. Concentrations of P-tau231P were measured in frontal cortex homogenates. We found significant correlations between CSF P-tau231P concentrations and scores of NFTs and HP-tau load in all neocortical regions studied. The score of NPs was correlated with CSF P-tau231P only within the frontal cortex. There was a correlation between P-tau231P in CSF and brain homogenates. These findings indicate that CSF P-tau231P may serve as an in vivo surrogate biomarker of neurofibrillary pathology in Alzheimer's disease.
Comment in
- No correlation between CSF tau protein phosphorylated at threonine 181 with neocortical neurofibrillary pathology in Alzheimer's disease.
Buerger K, Alafuzoff I, Ewers M, Pirttilä T, Zinkowski R, Hampel H. Buerger K, et al. Brain. 2007 Oct;130(Pt 10):e82. doi: 10.1093/brain/awm140. Epub 2007 Jul 5. Brain. 2007. PMID: 17615094 No abstract available.
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