Oriented loading of FtsK on KOPS - PubMed (original) (raw)

. 2006 Nov;13(11):1026-8.

doi: 10.1038/nsmb1159. Epub 2006 Oct 15.

Affiliations

• PMID: 17041597
• DOI: 10.1038/nsmb1159

Oriented loading of FtsK on KOPS

Sarah Bigot et al. Nat Struct Mol Biol. 2006 Nov.

Abstract

In Escherichia coli, the ATP-dependent DNA translocase FtsK transports DNA across the site of cell division and activates recombination by the XerCD recombinases at a specific site on the chromosome, dif, to ensure the last stages of chromosome segregation. DNA transport by FtsK is oriented by 8-base-pair asymmetric sequences ('KOPS'). Here we provide evidence that KOPS promote FtsK loading on DNA and that translocation is oriented at this step.

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Comment in

• FtsK: a groovy helicase.
  Strick TR, Quessada-Vial A. Strick TR, et al. Nat Struct Mol Biol. 2006 Nov;13(11):948-50. doi: 10.1038/nsmb1106-948. Nat Struct Mol Biol. 2006. PMID: 17082786 No abstract available.

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