Longitudinal study of physiologic insulin resistance and metabolic changes of puberty - PubMed (original) (raw)
Longitudinal study of physiologic insulin resistance and metabolic changes of puberty
Tamara S Hannon et al. Pediatr Res. 2006 Dec.
Abstract
Cross-sectional studies have shown that 1) adolescents are insulin resistant compared with prepubertal children and adults, 2) pubertal insulin resistance is likely mediated by growth hormone (GH), and 3) pubertal insulin resistance is associated with increased fat oxidation and decreased glucose oxidation. The aim of this study was to assess the validity of these cross-sectional observations by performing a longitudinal study in normal children during the prepubertal and pubertal periods. Nine healthy, normal weight, prepubertal children underwent hyperinsulinemic-euglycemic and hyperglycemic clamp studies for evaluation of insulin sensitivity and insulin secretion. Children had repeat evaluations during puberty. Consistent with cross-sectional observations, this longitudinal study demonstrated that during puberty: 1) insulin sensitivity decreased by approximately 50%, 2) the decrease in insulin sensitivity was compensated by a doubling in insulin secretion, and 3) the decrease in insulin sensitivity was independent of changes in percentage of body fat. Puberty was associated with increased total body lipolysis and decreased glucose oxidation. A novel observation is the demonstration of approximately 50% decrease in adiponectin levels at the pubertal time point. These metabolic changes are proposed to be partially mediated by increased GH secretion and are consistent with the Randle cycle of competition between glucose and fat oxidation.
Similar articles
- Testosterone treatment in adolescents with delayed puberty: changes in body composition, protein, fat, and glucose metabolism.
Arslanian S, Suprasongsin C. Arslanian S, et al. J Clin Endocrinol Metab. 1997 Oct;82(10):3213-20. doi: 10.1210/jcem.82.10.4293. J Clin Endocrinol Metab. 1997. PMID: 9329341 Clinical Trial. - Correlations between fatty acid and glucose metabolism. Potential explanation of insulin resistance of puberty.
Arslanian SA, Kalhan SC. Arslanian SA, et al. Diabetes. 1994 Jul;43(7):908-14. doi: 10.2337/diab.43.7.908. Diabetes. 1994. PMID: 8013756 - The effect of puberty on fat oxidation rates during exercise in overweight and normal-weight girls.
Chu L, Riddell MC, Schneiderman JE, McCrindle BW, Hamilton JK. Chu L, et al. J Appl Physiol (1985). 2014 Jan 1;116(1):76-82. doi: 10.1152/japplphysiol.00888.2013. Epub 2013 Nov 14. J Appl Physiol (1985). 2014. PMID: 24235101 - Insulin: the other anabolic hormone of puberty.
Caprio S. Caprio S. Acta Paediatr Suppl. 1999 Dec;88(433):84-7. doi: 10.1111/j.1651-2227.1999.tb14410.x. Acta Paediatr Suppl. 1999. PMID: 10626552 Review. - [Insulin resistance and hyperinsulinemia--risk factors of the metabolic syndrome in the pubertal population].
Otto Buczkowska E. Otto Buczkowska E. Endokrynol Diabetol Chor Przemiany Materii Wieku Rozw. 2005;11(2):109-14. Endokrynol Diabetol Chor Przemiany Materii Wieku Rozw. 2005. PMID: 15996341 Review. Polish.
Cited by
- The Impact of Vitamin D Receptor Gene Polymorphisms (FokI, ApaI, TaqI) in Correlation with Oxidative Stress and Hormonal and Dermatologic Manifestations in Polycystic Ovary Syndrome.
Talida V, Tudor SS, Mihaela I, Daniela-Rodica M, Gabriela A F, Lucia Maria P. Talida V, et al. Medicina (Kaunas). 2024 Sep 14;60(9):1501. doi: 10.3390/medicina60091501. Medicina (Kaunas). 2024. PMID: 39336541 Free PMC article. - Associations between blood glucose and early- and late-onset colorectal cancer: evidence from two prospective cohorts and Mendelian randomization analyses.
Luo C, Luo J, Zhang Y, Lu B, Li N, Zhou Y, Chen S, Wu S, Zhang Q, Dai M, Chen H. Luo C, et al. J Natl Cancer Cent. 2024 Jun 22;4(3):241-248. doi: 10.1016/j.jncc.2024.04.006. eCollection 2024 Sep. J Natl Cancer Cent. 2024. PMID: 39281721 Free PMC article. - Transition to self-management among emerging adults with type 1 diabetes: a mixed methods study.
Vitale RJ, Asher N, Shank K, Katyal B, Tinsley LJ, Garvey KC, Laffel LMB. Vitale RJ, et al. Front Clin Diabetes Healthc. 2024 May 7;5:1332159. doi: 10.3389/fcdhc.2024.1332159. eCollection 2024. Front Clin Diabetes Healthc. 2024. PMID: 38774897 Free PMC article. - New Clinical Markers of Oxidized Lipid-Associated Protein Damage in Children and Adolescents with Obesity.
Kostopoulou E, Varemmenou A, Kalaitzopoulou E, Papadea P, Skipitari M, Rojas Gil AP, Spiliotis BE, Fouzas S, Georgiou CD. Kostopoulou E, et al. Children (Basel). 2024 Mar 6;11(3):314. doi: 10.3390/children11030314. Children (Basel). 2024. PMID: 38539349 Free PMC article. - Intervention to increase physical activity and healthy eating among under-represented adolescents: GOAL trial protocol.
Robbins LB, Ling J, Pfeiffer KA, Kerver JM, Resnicow K, McCaffery H, Hilliard A, Hobbs L, Donald S, Kaciroti N. Robbins LB, et al. BMJ Open. 2024 Jan 3;14(1):e080437. doi: 10.1136/bmjopen-2023-080437. BMJ Open. 2024. PMID: 38171630 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
- K23 RR17250-01/RR/NCRR NIH HHS/United States
- K24-HD01357/HD/NICHD NIH HHS/United States
- M01-RR00084/RR/NCRR NIH HHS/United States
- R01 HD27503/HD/NICHD NIH HHS/United States
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous