NK cell regulation by SLAM family receptors and SAP-related adapters - PubMed (original) (raw)
Review
NK cell regulation by SLAM family receptors and SAP-related adapters
André Veillette. Immunol Rev. 2006 Dec.
Abstract
Signaling lymphocytic activating molecule (SLAM) family receptors and SLAM-associated protein (SAP)-related adapters play several important roles in the immune system. Natural killer (NK) cells express at least three members of the SLAM family. They are 2B4, NK, T- and B-cell antigen (NTB-A), and CD2-like receptor-activating cytotoxic cells (CRACC), which recognize their respective ligands CD48, NTB-A, and CRACC on target cells and possibly on other NK cells. In mature human NK cells, SLAM family receptors appear to have activating functions. In mature mouse NK cells, however, the only available information is for 2B4, which reportedly has the capacity to either stimulate or inhibit NK cell activation. The ability of SLAM family receptors to regulate NK cell functions seems to be largely dependent on their capacity to associate, by way of their cytoplasmic domain, with members of the SAP family of adapters, including SAP, Ewing's sarcoma-activated transcript-2 (EAT-2), and EAT-2-related transducer (ERT). By binding to SAP, SLAM family receptors are coupled to the Src kinase FynT, thereby evoking protein tyrosine phosphorylation signals. In human NK cells, SAP is likely to be crucial for the activating function of 2B4 and NTB-A but not of CRACC and also crucial for the activating function of 2B4 in mouse NK cells. EAT-2. SAP is ERT link SLAM family receptors to distinct, albeit poorly understood, signals. These two SAP-related adapters may be implicated in the inhibitory function of 2B4 observed in mouse NK cells. While much work remains to be carried out to fully understand the roles and mechanisms of action of the SLAM and SAP families in human and mouse NK cells, the published findings clearly establish that these molecules have important functions in NK cell biology.
Similar articles
- Importance and mechanism of 'switch' function of SAP family adapters.
Veillette A, Dong Z, Pérez-Quintero LA, Zhong MC, Cruz-Munoz ME. Veillette A, et al. Immunol Rev. 2009 Nov;232(1):229-39. doi: 10.1111/j.1600-065X.2009.00824.x. Immunol Rev. 2009. PMID: 19909367 - Molecular dissection of 2B4 signaling: implications for signal transduction by SLAM-related receptors.
Chen R, Relouzat F, Roncagalli R, Aoukaty A, Tan R, Latour S, Veillette A. Chen R, et al. Mol Cell Biol. 2004 Jun;24(12):5144-56. doi: 10.1128/MCB.24.12.5144-5156.2004. Mol Cell Biol. 2004. PMID: 15169881 Free PMC article. - Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation.
Tangye SG, Nichols KE, Hare NJ, van de Weerdt BC. Tangye SG, et al. J Immunol. 2003 Sep 1;171(5):2485-95. doi: 10.4049/jimmunol.171.5.2485. J Immunol. 2003. PMID: 12928397 - Regulation of cellular and humoral immune responses by the SLAM and SAP families of molecules.
Ma CS, Nichols KE, Tangye SG. Ma CS, et al. Annu Rev Immunol. 2007;25:337-79. doi: 10.1146/annurev.immunol.25.022106.141651. Annu Rev Immunol. 2007. PMID: 17201683 Review. - Molecular and cellular pathogenesis of X-linked lymphoproliferative disease.
Nichols KE, Ma CS, Cannons JL, Schwartzberg PL, Tangye SG. Nichols KE, et al. Immunol Rev. 2005 Feb;203:180-99. doi: 10.1111/j.0105-2896.2005.00230.x. Immunol Rev. 2005. PMID: 15661030 Review.
Cited by
- Single-cell profiling identifies a CD8bright CD244bright Natural Killer cell subset that reflects disease activity in HLA-A29-positive birdshot chorioretinopathy.
Nath PR, Maclean M, Nagarajan V, Lee JW, Yakin M, Kumar A, Nadali H, Schmidt B, Kaya KD, Kodati S, Young A, Caspi RR, Kuiper JJW, Sen HN. Nath PR, et al. Nat Commun. 2024 Jul 31;15(1):6443. doi: 10.1038/s41467-024-50472-0. Nat Commun. 2024. PMID: 39085199 Free PMC article. - Kinome and phosphoproteome reprogramming underlies the aberrant immune responses in critically ill COVID-19 patients.
Kaneko T, Ezra S, Abdo R, Voss C, Zhong S, Liu X, Hovey O, Slessarev M, Van Nynatten LR, Ye M, Fraser DD, Li SS. Kaneko T, et al. Clin Proteomics. 2024 Feb 22;21(1):13. doi: 10.1186/s12014-024-09457-w. Clin Proteomics. 2024. PMID: 38389037 Free PMC article. - Novel insights into the pathogenesis of follicular lymphoma by molecular profiling of localized and systemic disease forms.
Kalmbach S, Grau M, Zapukhlyak M, Leich E, Jurinovic V, Hoster E, Staiger AM, Kurz KS, Weigert O, Gaitzsch E, Passerini V, Engelhard M, Herfarth K, Beiske K, Micci F, Möller P, Bernd HW, Feller AC, Klapper W, Stein H, Hansmann ML, Hartmann S, Dreyling M, Holte H, Lenz G, Rosenwald A, Ott G, Horn H; German Lymphoma Alliance (GLA). Kalmbach S, et al. Leukemia. 2023 Oct;37(10):2058-2065. doi: 10.1038/s41375-023-01995-w. Epub 2023 Aug 10. Leukemia. 2023. PMID: 37563306 Free PMC article. - Prospects for NK-based immunotherapy of chronic HBV infection.
Jin X, Bi J. Jin X, et al. Front Immunol. 2022 Dec 15;13:1084109. doi: 10.3389/fimmu.2022.1084109. eCollection 2022. Front Immunol. 2022. PMID: 36591230 Free PMC article. Review. - The War Is on: The Immune System against Glioblastoma-How Can NK Cells Drive This Battle?
da Silva LHR, Catharino LCC, da Silva VJ, Evangelista GCM, Barbuto JAM. da Silva LHR, et al. Biomedicines. 2022 Feb 8;10(2):400. doi: 10.3390/biomedicines10020400. Biomedicines. 2022. PMID: 35203609 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous