Expression of p-STAT3 in human gastric carcinoma: significant correlation in tumour invasion and prognosis - PubMed (original) (raw)
Affiliations
- PMID: 17203226
Expression of p-STAT3 in human gastric carcinoma: significant correlation in tumour invasion and prognosis
Yuichi Yakata et al. Int J Oncol. 2007 Feb.
Abstract
Signal transducers and activators of transcription (STATs) belong to a family of transcription factors activated in response to cytokines and growth factors. Constitutive activation of STAT3 has been observed in a growing number of tumour-derived cell lines, as well as in tumor specimens from human cancers. Our aim was to determine the relationship between the expression of phosphorylated STAT3 (p-STAT3) and clinicopathological factors in human gastric adenocarcinoma. One-hundred and eleven cases of surgically resected human gastric adenocarcinoma were studied by immunohistochemistry. Fifty-five (49.5%) cases showed positive staining for the p-STAT3 proteins. The expression of p-STAT3 was significantly correlated with several clinicopathological factors. Moreover, expression of p-STAT3 was detected by Western blot analysis in 2 different kinds of cultured human gastric carcinoma cell lines and 4 cases of gastric carcinoma tissue obtained at surgery. Western blot analysis confirmed the presence of p-STAT3 in these specimens. In univariate survival analysis, p-STAT3 expression was associated with inferior survival (p<0.05). Constitutive activation of STAT3 may play an important role in the tumorigenesis of gastric adenocarcinoma, and the detailed mechanism of STAT3 signaling pathway in gastric adenocarcinoma deserves further investigation.
Similar articles
- Activation of STAT3 is a marker of poor prognosis in human colorectal cancer.
Kusaba T, Nakayama T, Yamazumi K, Yakata Y, Yoshizaki A, Inoue K, Nagayasu T, Sekine I. Kusaba T, et al. Oncol Rep. 2006 Jun;15(6):1445-51. Oncol Rep. 2006. PMID: 16685378 - Expression of activated signal transducer and activator of transcription 3 predicts expression of vascular endothelial growth factor in and angiogenic phenotype of human gastric cancer.
Gong W, Wang L, Yao JC, Ajani JA, Wei D, Aldape KD, Xie K, Sawaya R, Huang S. Gong W, et al. Clin Cancer Res. 2005 Feb 15;11(4):1386-93. doi: 10.1158/1078-0432.CCR-04-0487. Clin Cancer Res. 2005. PMID: 15746037 - Phospho-Stat3 expression and correlation with VEGF, p53, and Bcl-2 in gastric carcinoma using tissue microarray.
Choi JH, Ahn MJ, Park CK, Han HX, Kwon SJ, Lee YY, Kim IS. Choi JH, et al. APMIS. 2006 Sep;114(9):619-25. doi: 10.1111/j.1600-0463.2006.apm_401.x. APMIS. 2006. PMID: 16948814 - Targeting STAT3 in gastric cancer.
Giraud AS, Menheniott TR, Judd LM. Giraud AS, et al. Expert Opin Ther Targets. 2012 Sep;16(9):889-901. doi: 10.1517/14728222.2012.709238. Epub 2012 Jul 26. Expert Opin Ther Targets. 2012. PMID: 22834702 Review.
Cited by
- Phosphorylation of signal transducer and activator of transcription 3 (STAT3) correlates with Her-2 status, carbonic anhydrase 9 expression and prognosis in esophageal cancer.
Schoppmann SF, Jesch B, Friedrich J, Jomrich G, Maroske F, Birner P. Schoppmann SF, et al. Clin Exp Metastasis. 2012 Aug;29(6):615-24. doi: 10.1007/s10585-012-9475-3. Epub 2012 Apr 8. Clin Exp Metastasis. 2012. PMID: 22484976 - Hyperactive gp130/STAT3-driven gastric tumourigenesis promotes submucosal tertiary lymphoid structure development.
Hill DG, Yu L, Gao H, Balic JJ, West A, Oshima H, McLeod L, Oshima M, Gallimore A, D'Costa K, Bhathal PS, Sievert W, Ferrero RL, Jenkins BJ, Jones GW. Hill DG, et al. Int J Cancer. 2018 Jul 1;143(1):167-178. doi: 10.1002/ijc.31298. Epub 2018 Feb 19. Int J Cancer. 2018. PMID: 29417587 Free PMC article. - Proteomic identification of the oncoprotein STAT3 as a target of a novel Skp1 inhibitor.
Cheng X, Liu YQ, Wang GZ, Yang LN, Lu YZ, Li XC, Zhou B, Qu LW, Wang XL, Cheng YX, Liu J, Tao SC, Zhou GB. Cheng X, et al. Oncotarget. 2017 Jan 10;8(2):2681-2693. doi: 10.18632/oncotarget.13153. Oncotarget. 2017. PMID: 27835873 Free PMC article. - IL-11 is a parietal cell cytokine that induces atrophic gastritis.
Howlett M, Chalinor HV, Buzzelli JN, Nguyen N, van Driel IR, Bell KM, Fox JG, Dimitriadis E, Menheniott TR, Giraud AS, Judd LM. Howlett M, et al. Gut. 2012 Oct;61(10):1398-409. doi: 10.1136/gutjnl-2011-300539. Epub 2011 Dec 16. Gut. 2012. PMID: 22180059 Free PMC article. - The Role of STAT3 in Thyroid Cancer.
Sosonkina N, Starenki D, Park JI. Sosonkina N, et al. Cancers (Basel). 2014 Mar 6;6(1):526-44. doi: 10.3390/cancers6010526. Cancers (Basel). 2014. PMID: 24662939 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous