Frizzled/PCP signalling: a conserved mechanism regulating cell polarity and directed motility - PubMed (original) (raw)

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doi: 10.1038/nrg2042.

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• PMID: 17230199
• DOI: 10.1038/nrg2042

Review

Frizzled/PCP signalling: a conserved mechanism regulating cell polarity and directed motility

Jessica R K Seifert et al. Nat Rev Genet. 2007 Feb.

Abstract

Signalling through Frizzled (Fz)/planar cell polarity (PCP) is a conserved mechanism that polarizes cells along specific axes in a tissue. Genetic screens in Drosophila melanogaster pioneered the discovery of core PCP factors, which regulate the orientation of hairs on wings and facets in eyes. Recent genetic evidence shows that the Fz/PCP pathway is conserved in vertebrates and is crucial for disparate processes as gastrulation and sensory cell orientation. Fz/PCP signalling depends on complex interactions between core components, leading to their asymmetric distribution and ultimately polarized activity in a cell. Whereas several mechanistic aspects of PCP have been uncovered, the global coordination of this polarization remains debated.

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