New therapeutic strategies for the treatment of acute lymphoblastic leukaemia - PubMed (original) (raw)
Review
doi: 10.1038/nrd2240.
Affiliations
- PMID: 17268486
- DOI: 10.1038/nrd2240
Review
New therapeutic strategies for the treatment of acute lymphoblastic leukaemia
Ching-Hon Pui et al. Nat Rev Drug Discov. 2007 Feb.
Abstract
Although contemporary treatments cure more than 80% of children with acute lymphoblastic leukaemia (ALL), some patients require intensive treatment and many patients still develop serious acute and late complications owing to the side effects of the treatments. Furthermore, the survival rate for adults with ALL remains below 40%. Therefore, new treatment strategies are needed to improve not only the cure rate but also the quality of life of these patients. Here, we discuss emerging new treatments that might improve the clinical outcome of patients with ALL. These include new formulations of existing chemotherapeutic agents, new antimetabolites and nucleoside analogues, monoclonal antibodies against leukaemia-associated antigens, and molecular therapies that target genetic abnormalities of the leukaemic cells and their affected signalling pathways.
Similar articles
- New therapeutic strategies in acute lymphoblastic leukemia.
Jeha S. Jeha S. Semin Hematol. 2009 Jan;46(1):76-88. doi: 10.1053/j.seminhematol.2008.09.009. Semin Hematol. 2009. PMID: 19100370 Review. - Emerging drugs for adult acute lymphoblastic leukaemia.
Thomas X. Thomas X. Expert Opin Emerg Drugs. 2005 Aug;10(3):591-617. doi: 10.1517/14728214.10.3.591. Expert Opin Emerg Drugs. 2005. PMID: 16083331 Review. - [A brief history of treatments for childhood acute lymphoblastic leukaemia].
Leverger G, Baruchel A, Schaison G. Leverger G, et al. Bull Acad Natl Med. 2009 Oct;193(7):1495-9; discussion 1499-500. Bull Acad Natl Med. 2009. PMID: 20669630 French. - [Individualized cancer treatment. Illustrated by acute lymphoblastic leukemia in children].
Schmiegelow K. Schmiegelow K. Ugeskr Laeger. 2001 Feb 19;163(8):1062-6. Ugeskr Laeger. 2001. PMID: 11242663 Review. Danish. - New antileukemic agents.
Mantadakis E, Kalmanti M. Mantadakis E, et al. Pediatr Hematol Oncol. 2003 Apr-May;20(3):173-85. Pediatr Hematol Oncol. 2003. PMID: 12637214 Review.
Cited by
- Panobinostat (LBH589) increase survival in adult xenografic model of acute lymphoblastic leukemia with t(4;11) but promotes antagonistic effects in combination with MTX and 6MP.
Moreno DA, Junior HLR, Laranjeira ABA, Cruzeiro GAV, Borges KS, Salomão KB, Ramalho FS, Yunes JA, Silva CLA, Rego EM, Scrideli CA, Tone LG. Moreno DA, et al. Med Oncol. 2022 Sep 29;39(12):216. doi: 10.1007/s12032-022-01813-w. Med Oncol. 2022. PMID: 36175721 - High-valency Anti-CD99 Antibodies Toward the Treatment of T Cell Acute Lymphoblastic Leukemia.
Romero LA, Hattori T, Ali MAE, Ketavarapu G, Koide A, Park CY, Koide S. Romero LA, et al. J Mol Biol. 2022 Mar 15;434(5):167402. doi: 10.1016/j.jmb.2021.167402. Epub 2021 Dec 24. J Mol Biol. 2022. PMID: 34958778 Free PMC article. - Nanomedicine for Immunotherapy Targeting Hematological Malignancies: Current Approaches and Perspective.
Allegra A, Gioacchino MD, Tonacci A, Petrarca C, Gangemi S. Allegra A, et al. Nanomaterials (Basel). 2021 Oct 21;11(11):2792. doi: 10.3390/nano11112792. Nanomaterials (Basel). 2021. PMID: 34835555 Free PMC article. Review. - BAG1 down-regulation increases chemo-sensitivity of acute lymphoblastic leukaemia cells.
Mariotto E, Corallo D, Pantile M, Giarin E, Pigazzi M, Basso G, Viola G, Aveic S. Mariotto E, et al. J Cell Mol Med. 2021 Sep;25(18):9060-9065. doi: 10.1111/jcmm.16822. Epub 2021 Aug 17. J Cell Mol Med. 2021. PMID: 34402163 Free PMC article. - Mediator subunit MED1 is required for E2A-PBX1-mediated oncogenic transcription and leukemic cell growth.
Lee YL, Ito K, Pi WC, Lin IH, Chu CS, Malik S, Cheng IH, Chen WY, Roeder RG. Lee YL, et al. Proc Natl Acad Sci U S A. 2021 Feb 9;118(6):e1922864118. doi: 10.1073/pnas.1922864118. Proc Natl Acad Sci U S A. 2021. PMID: 33542097 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources