Prognostic nomogram and index for overall survival in previously untreated patients with chronic lymphocytic leukemia - PubMed (original) (raw)
. 2007 Jun 1;109(11):4679-85.
doi: 10.1182/blood-2005-12-051458. Epub 2007 Feb 13.
Susan O'Brien, Xuemei Wang, Stefan Faderl, Alessandra Ferrajoli, Kim-Anh Do, Jorge Cortes, Deborah Thomas, Guillermo Garcia-Manero, Charles Koller, Miloslav Beran, Francis Giles, Farhad Ravandi, Susan Lerner, Hagop Kantarjian, Michael Keating
Affiliations
- PMID: 17299097
- DOI: 10.1182/blood-2005-12-051458
Free article
Prognostic nomogram and index for overall survival in previously untreated patients with chronic lymphocytic leukemia
William G Wierda et al. Blood. 2007.
Free article
Abstract
The clinical course for patients with chronic lymphocytic leukemia is extremely heterogeneous. The Rai and Binet staging systems have been used to risk-stratify patients; most patients present with early-stage disease. We evaluated a group of previously untreated patients with chronic lymphocytic leukemia (CLL) at initial presentation to University of Texas M. D. Anderson Cancer Center to identify independent characteristics that predict for overall survival. Clinical and routine laboratory characteristics for 1674 previously untreated patients who presented for evaluation of CLL from 1981 to 2004 were included. Univariate and multivariate analyses identified several patient characteristics at presentation that predicted for overall survival in previously untreated patients with CLL. A multivariate Cox proportional hazards model was developed, including the following independent characteristics: age, beta-2 microglobulin, absolute lymphocyte count, sex, Rai stage, and number of involved lymph node groups. Inclusion of patients from a single institution and the proportion of patients younger than 65 years may limit this model. A weighted prognostic model, or nomogram, predictive for overall survival was constructed using these 6 characteristics for 5- and 10-year survival probability and estimated median survival time. This prognostic model may help patients and clinicians in clinical decision making as well as in clinical research and clinical trial design.
Similar articles
- Italian external and multicentric validation of the MD Anderson Cancer Center nomogram and prognostic index for chronic lymphocytic leukaemia patients: analysis of 1502 cases.
Gentile M, Mauro FR, Rossi D, Vincelli I, Tripepi G, Recchia AG, De Stefano L, Campanelli M, Giannarelli D, Bossio S, Morabito L, Vigna E, Gaidano G, Foà R, Morabito F. Gentile M, et al. Br J Haematol. 2014 Oct;167(2):224-32. doi: 10.1111/bjh.13032. Epub 2014 Jul 11. Br J Haematol. 2014. PMID: 25041609 - IGHV gene mutational status and 17p deletion are independent molecular predictors in a comprehensive clinical-biological prognostic model for overall survival prediction in chronic lymphocytic leukemia.
Bulian P, Rossi D, Forconi F, Del Poeta G, Bertoni F, Zucca E, Montillo M, Pozzato G, D'Arena G, Efremov DG, Marasca R, Lauria F, Gaidano G, Gattei V, Laurenti L. Bulian P, et al. J Transl Med. 2012 Jan 30;10:18. doi: 10.1186/1479-5876-10-18. J Transl Med. 2012. PMID: 22289136 Free PMC article. - Multicentre validation of a prognostic index for overall survival in chronic lymphocytic leukaemia.
Bulian P, Tarnani M, Rossi D, Forconi F, Del Poeta G, Bertoni F, Zucca E, Montillo M, Pozzato G, Deaglio S, D'Arena G, Efremov D, Marasca R, Lauria F, Gattei V, Gaidano G, Laurenti L. Bulian P, et al. Hematol Oncol. 2011 Jun;29(2):91-9. doi: 10.1002/hon.959. Epub 2010 Jul 28. Hematol Oncol. 2011. PMID: 20669154 - The utility of a prognostic index for predicting time to first treatment in early chronic lymphocytic leukemia: the GIMEMA experience.
Molica S, Mauro FR, Callea V, Giannarelli D, Lauria F, Rotoli B, Cortelezzi A, Liso V, Foà R. Molica S, et al. Haematologica. 2010 Mar;95(3):464-9. doi: 10.3324/haematol.2009.011767. Epub 2009 Nov 10. Haematologica. 2010. PMID: 19903673 Free PMC article. - Presenting features and outcome of chronic lymphocytic leukemia patients diagnosed at age 80 years or more. An ICLLSG study.
Bairey O, Ruchlemer R, Rahimi-Levene N, Herishanu Y, Braester A, Berrebi A, Polliack A, Klepfish A, Shvidel L; Israeli CLL Study Group (ICLLSG). Bairey O, et al. Ann Hematol. 2011 Oct;90(10):1123-9. doi: 10.1007/s00277-011-1259-3. Epub 2011 May 26. Ann Hematol. 2011. PMID: 21614458 Review.
Cited by
- Advances in Microflow Cytometry-Based Molecular Detection Methods for Improved Future MDS Cancer Diagnosis.
Gonsalves M, Escobar A, Altarabishi AD, Xu CQ. Gonsalves M, et al. Curr Issues Mol Biol. 2024 Jul 26;46(8):8053-8070. doi: 10.3390/cimb46080476. Curr Issues Mol Biol. 2024. PMID: 39194693 Free PMC article. Review. - Albumin-to-Globulin Ratio Combined with Neutrophil-to-Lymphocyte Ratio as a Prognostic Predictor in Multiple Myeloma with Renal Impairment.
Zhang Y, Yao X, Zhang Y, Chen Z, Qin Z, Cai Y, Xia W, Hu H. Zhang Y, et al. Blood Lymphat Cancer. 2024 Jul 2;14:49-62. doi: 10.2147/BLCTT.S468836. eCollection 2024. Blood Lymphat Cancer. 2024. PMID: 38974337 Free PMC article. - Albumin-to-alkaline phosphatase ratio as a novel prognostic indicator in patients undergoing peritoneal dialysis: a propensity score matching analysis.
Xia W, Hua X, Sun D, Xie X, Hu H. Xia W, et al. Front Med (Lausanne). 2024 Apr 18;11:1302603. doi: 10.3389/fmed.2024.1302603. eCollection 2024. Front Med (Lausanne). 2024. PMID: 38698782 Free PMC article. - Predicting survival in patients with buccal cancer: A study based on SEER database and external validation in China.
Tan Y, Huang G, Hu J, Zhao S, Li Y, Wen Z, Wang L, Chen S, Chen R, Cao H, Li J. Tan Y, et al. Cancer Med. 2024 Feb;13(3):e6907. doi: 10.1002/cam4.6907. Epub 2024 Jan 29. Cancer Med. 2024. PMID: 38284829 Free PMC article. Clinical Trial. - Treatment of Chronic Lymphocytic Leukemia in the Personalized Medicine Era.
Sánchez Suárez MDM, Martín Roldán A, Alarcón-Payer C, Rodríguez-Gil MÁ, Poquet-Jornet JE, Puerta Puerta JM, Jiménez Morales A. Sánchez Suárez MDM, et al. Pharmaceutics. 2023 Dec 29;16(1):55. doi: 10.3390/pharmaceutics16010055. Pharmaceutics. 2023. PMID: 38258066 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials