Stressing the role of FoxO proteins in lifespan and disease - PubMed (original) (raw)
Review
doi: 10.1038/nrm2190.
Affiliations
- PMID: 17522590
- DOI: 10.1038/nrm2190
Review
Stressing the role of FoxO proteins in lifespan and disease
Armando van der Horst et al. Nat Rev Mol Cell Biol. 2007 Jun.
Abstract
Members of the class O of forkhead box transcription factors (FoxO) have important roles in metabolism, cellular proliferation, stress tolerance and probably lifespan. The activity of FoxOs is tightly regulated by post-translational modifications, including phosphorylation, acetylation and ubiquitylation. Several of the enzymes that regulate the turnover of these post-translational modifications are shared between FoxO and p53. These regulatory enzymes affect FoxO and p53 function in an opposite manner. This shared yet opposing regulatory network between FoxOs and p53 may underlie a 'trade-off' between disease and lifespan.
Similar articles
- Applications of post-translational modifications of FoxO family proteins in biological functions.
Zhao Y, Wang Y, Zhu WG. Zhao Y, et al. J Mol Cell Biol. 2011 Oct;3(5):276-82. doi: 10.1093/jmcb/mjr013. Epub 2011 Jun 13. J Mol Cell Biol. 2011. PMID: 21669942 Review. - FOXO transcription factors in the regulatory networks of longevity.
Daitoku H, Fukamizu A. Daitoku H, et al. J Biochem. 2007 Jun;141(6):769-74. doi: 10.1093/jb/mvm104. J Biochem. 2007. PMID: 17569704 Review. - Structure/function relationships underlying regulation of FOXO transcription factors.
Obsil T, Obsilova V. Obsil T, et al. Oncogene. 2008 Apr 7;27(16):2263-75. doi: 10.1038/onc.2008.20. Oncogene. 2008. PMID: 18391969 Review. - The role of Forkhead-box Class O (FoxO) transcription factors in cancer: a target for the management of cancer.
Reagan-Shaw S, Ahmad N. Reagan-Shaw S, et al. Toxicol Appl Pharmacol. 2007 Nov 1;224(3):360-8. doi: 10.1016/j.taap.2006.12.003. Epub 2006 Dec 15. Toxicol Appl Pharmacol. 2007. PMID: 17275054 Review. - Post-translational regulation of FOXO.
Xie Q, Chen J, Yuan Z. Xie Q, et al. Acta Biochim Biophys Sin (Shanghai). 2012 Nov;44(11):897-901. doi: 10.1093/abbs/gms067. Epub 2012 Aug 30. Acta Biochim Biophys Sin (Shanghai). 2012. PMID: 22935512 Review.
Cited by
- Glutathione suppresses cerebral infarct volume and cell death after ischemic injury: involvement of FOXO3 inactivation and Bcl2 expression.
Song J, Park J, Oh Y, Lee JE. Song J, et al. Oxid Med Cell Longev. 2015;2015:426069. doi: 10.1155/2015/426069. Epub 2015 Feb 4. Oxid Med Cell Longev. 2015. PMID: 25722793 Free PMC article. - The transcription factors CREBH, PPARa, and FOXO1 as critical hepatic mediators of diet-induced metabolic dysregulation.
Yang Z, Roth K, Agarwal M, Liu W, Petriello MC. Yang Z, et al. J Nutr Biochem. 2021 Sep;95:108633. doi: 10.1016/j.jnutbio.2021.108633. Epub 2021 Mar 28. J Nutr Biochem. 2021. PMID: 33789150 Free PMC article. Review. - Forkhead transcription factor FOXO3a protein activates nuclear factor κB through B-cell lymphoma/leukemia 10 (BCL10) protein and promotes tumor cell survival in serum deprivation.
Li Z, Zhang H, Chen Y, Fan L, Fang J. Li Z, et al. J Biol Chem. 2012 May 18;287(21):17737-17745. doi: 10.1074/jbc.M111.291708. Epub 2012 Apr 2. J Biol Chem. 2012. PMID: 22474286 Free PMC article. - FOXO3a acts to suppress DNA double-strand break-induced mutations.
White RR, Maslov AY, Lee M, Wilner SE, Levy M, Vijg J. White RR, et al. Aging Cell. 2020 Sep;19(9):e13184. doi: 10.1111/acel.13184. Epub 2020 Jul 28. Aging Cell. 2020. PMID: 32720744 Free PMC article. - FOXO3 gene variants and human aging: coding variants may not be key players.
Donlon TA, Curb JD, He Q, Grove JS, Masaki KH, Rodriguez B, Elliott A, Willcox DC, Willcox BJ. Donlon TA, et al. J Gerontol A Biol Sci Med Sci. 2012 Nov;67(11):1132-9. doi: 10.1093/gerona/gls067. Epub 2012 Mar 28. J Gerontol A Biol Sci Med Sci. 2012. PMID: 22459618 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous