Gene-specific control of inflammation by TLR-induced chromatin modifications - PubMed (original) (raw)
. 2007 Jun 21;447(7147):972-8.
doi: 10.1038/nature05836. Epub 2007 May 30.
Affiliations
- PMID: 17538624
- DOI: 10.1038/nature05836
Gene-specific control of inflammation by TLR-induced chromatin modifications
Simmie L Foster et al. Nature. 2007.
Erratum in
- Nature. 2008 Jan 3;451(7174):102
Abstract
Toll-like receptors (TLRs) induce a multi-component inflammatory response that must be tightly regulated to avoid tissue damage. Most known regulatory mechanisms target TLR signalling pathways and thus broadly inhibit multiple aspects of the inflammatory response. Given the functional diversity of TLR-induced genes, we proposed that additional, gene-specific regulatory mechanisms exist to allow individual aspects of the TLR-induced response to be differentially regulated. Using an in vitro system of lipopolysaccharide tolerance in murine macrophages, we show that TLR-induced genes fall into two categories on the basis of their functions and regulatory requirements. We demonstrate that representatives from the two classes acquire distinct patterns of TLR-induced chromatin modifications. These gene-specific chromatin modifications are associated with transient silencing of one class of genes, which includes pro-inflammatory mediators, and priming of the second class, which includes antimicrobial effectors. These findings illustrate an adaptive response in macrophages and reveal component-specific regulation of inflammation.
Comment in
- Immunology: Short-term memory.
Gantner BN, Singh H. Gantner BN, et al. Nature. 2007 Jun 21;447(7147):916-7. doi: 10.1038/447916a. Nature. 2007. PMID: 17581569 No abstract available.
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