Bub1: escapades in a cellular world - PubMed (original) (raw)
Review
. 2007 Jul 15;6(14):1699-704.
doi: 10.4161/cc.6.14.4493. Epub 2007 May 25.
Affiliations
- PMID: 17643075
- DOI: 10.4161/cc.6.14.4493
Review
Bub1: escapades in a cellular world
Grace L Williams et al. Cell Cycle. 2007.
Abstract
The spindle assembly checkpoint is an important surveillance mechanism that ensures high fidelity mitotic chromosome segregation. This is accomplished by monitoring whether sister chromatids lack tension or attachment to spindle microtubules. It is mediated by checkpoint complexes or individual proteins that inhibit the ubiquitin ligase activity of the anaphase-promoting complex/cyclosome (APC/C) via targeting of the Cdc20 regulatory subunit. The Bub1 kinase is a key spindle checkpoint regulatory protein. Bub1 also plays more pleiotropic roles. Thus, Bub1 is required for assembly of a functional inner centromere, sister chromatid cohesion via targeting of the Shugoshin protein, and metaphase congression. Evidence based on Bub1 mutations in colorectal cancers suggests it might be a driving force in tumorigenesis via generation of chromosomal instability (CIN) and aneuploidy. Recently we reported a surveillance mechanism linking loss of Bub1 to activation of the p53 pathway, specifically premature cell senescence in normal human fibroblasts. Interestingly, SV40 large T antigen (LT) targets Bub1 and this is correlated with oncogenic transformation and compromise of the spindle checkpoint. Future studies on Bub1 combining genetic approaches with analysis of LT perturbations are likely to yield further insight.
Similar articles
- Bub1 and aurora B cooperate to maintain BubR1-mediated inhibition of APC/CCdc20.
Morrow CJ, Tighe A, Johnson VL, Scott MI, Ditchfield C, Taylor SS. Morrow CJ, et al. J Cell Sci. 2005 Aug 15;118(Pt 16):3639-52. doi: 10.1242/jcs.02487. Epub 2005 Jul 26. J Cell Sci. 2005. PMID: 16046481 - Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint.
Tang Z, Shu H, Oncel D, Chen S, Yu H. Tang Z, et al. Mol Cell. 2004 Nov 5;16(3):387-97. doi: 10.1016/j.molcel.2004.09.031. Mol Cell. 2004. PMID: 15525512 - Bub1 multitasking in mitosis.
Yu H, Tang Z. Yu H, et al. Cell Cycle. 2005 Feb;4(2):262-5. Epub 2005 Feb 21. Cell Cycle. 2005. PMID: 15655378 - Bub1 and BubR1: at the interface between chromosome attachment and the spindle checkpoint.
Elowe S. Elowe S. Mol Cell Biol. 2011 Aug;31(15):3085-93. doi: 10.1128/MCB.05326-11. Epub 2011 May 31. Mol Cell Biol. 2011. PMID: 21628528 Free PMC article. Review. - Mutual regulation between the spindle checkpoint and APC/C.
Kim S, Yu H. Kim S, et al. Semin Cell Dev Biol. 2011 Aug;22(6):551-8. doi: 10.1016/j.semcdb.2011.03.008. Epub 2011 Mar 23. Semin Cell Dev Biol. 2011. PMID: 21439394 Free PMC article. Review.
Cited by
- Sudden unexpected postnatal collapse and BUB1B mutation: first forensic case report.
Esposito M, Sessa F, Nannola C, Pignotti MS, Greco P, Salerno M. Esposito M, et al. Int J Legal Med. 2024 Sep;138(5):2049-2055. doi: 10.1007/s00414-024-03231-1. Epub 2024 Apr 26. Int J Legal Med. 2024. PMID: 38664248 Free PMC article. - Screening of Hub Genes in Hepatocellular Carcinoma Based on Network Analysis and Machine Learning.
Zhang Y, Xie Y, Huang X, Zhang L, Shu K. Zhang Y, et al. Comput Math Methods Med. 2022 Nov 28;2022:7300788. doi: 10.1155/2022/7300788. eCollection 2022. Comput Math Methods Med. 2022. PMID: 36479313 Free PMC article. - Cross-regulome profiling of RNA polymerases highlights the regulatory role of polymerase III on mRNA transcription by maintaining local chromatin architecture.
Jiang Y, Huang J, Tian K, Yi X, Zheng H, Zhu Y, Guo T, Ji X. Jiang Y, et al. Genome Biol. 2022 Nov 28;23(1):246. doi: 10.1186/s13059-022-02812-w. Genome Biol. 2022. PMID: 36443871 Free PMC article. - bub1 as a potential oncogene and a prognostic biomarker for neuroblastoma.
Song J, Ni C, Dong X, Sheng C, Qu Y, Zhu L. Song J, et al. Front Oncol. 2022 Sep 27;12:988415. doi: 10.3389/fonc.2022.988415. eCollection 2022. Front Oncol. 2022. PMID: 36237324 Free PMC article. - Identification and Validation of a Potential Stemness-Associated Biomarker in Hepatocellular Carcinoma.
Zhang Y, Zhang R, Zeng L, Wang H, Peng R, Zhang M, Zhang H, Yang Z, Gao L, Wang M, Liu J. Zhang Y, et al. Stem Cells Int. 2022 Jul 11;2022:1534593. doi: 10.1155/2022/1534593. eCollection 2022. Stem Cells Int. 2022. PMID: 35859724 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
Miscellaneous