The human Mi-2/NuRD complex and gene regulation - PubMed (original) (raw)
Review
. 2007 Aug 13;26(37):5433-8.
doi: 10.1038/sj.onc.1210611.
Affiliations
- PMID: 17694084
- DOI: 10.1038/sj.onc.1210611
Review
The human Mi-2/NuRD complex and gene regulation
S A Denslow et al. Oncogene. 2007.
Abstract
The Mi-2/nucleosome remodeling and deacetylase (NuRD) complex is an abundant deacetylase complex with a broad cellular and tissue distribution. It is unique in that it couples histone deacetylation and chromatin remodeling ATPase activities in the same complex. A decade of research has uncovered a number of interesting connections between Mi-2/NuRD and gene regulation. The subunit composition of the enzyme appears to vary with cell type and in response to physiologic signals within a tissue. Here, we review the known subunits of the complex, their connections to signaling networks, and their association with cancer. In addition, we propose a working model that integrates the known biochemical properties of the enzyme with emerging models on how chromatin structure and modification relate to gene activity.
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